Genes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling

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dc.contributor.authorJ D Yang-
dc.contributor.authorS Y Seol-
dc.contributor.authorS H Leem-
dc.contributor.authorY H Kim-
dc.contributor.authorZ Sun-
dc.contributor.authorJ S Lee-
dc.contributor.authorS S Thorgeirsson-
dc.contributor.authorIn-Sun Chu-
dc.contributor.authorL R Roberts-
dc.contributor.authorK J Kang-
dc.date.accessioned2017-04-19T09:25:59Z-
dc.date.available2017-04-19T09:25:59Z-
dc.date.issued2011-
dc.identifier.issn1011-8934-
dc.identifier.uri10.3346/jkms.2011.26.11.1428ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10418-
dc.description.abstractGene expression is suppressed by DNA methylation. The goal of this study was to identify genes whose CpG site methylation and mRNA expression are associated with recurrence after surgical resection for hepatocellular carcinoma (HCC). Sixty-two HCCs were examined by both whole genome DNA methylation and transcriptome analysis. The Cox model was used to select genes associated with recurrence. A validation was performed in an independent cohort of 66 HCC patients. Among fifty-nine common genes, increased CpG site methylation and decreased mRNA expression were associated with recurrence for 12 genes (Group A), whereas decreased CpG site methylation and increased mRNA expression were associated with recurrence for 25 genes (Group B). The remaining 22 genes were defined as Group C. Complement factor H (CFH) and myosin VIIA and Rab interacting protein (MYRIP) in Group A; proline/serine-rich coiled-coil 1 (PSRC1), meiotic recombination 11 homolog A (MRE11A), and myosin IE (MYO1E) in Group B; and autophagy-related protein LC3 A (MAP1LC3A), and NADH dehydrogenase 1 alpha subcomplex assembly factor 1 (NDUFAF1) in Group C were validated. In conclusion, potential tumor suppressor (CFH, MYRIP) and oncogenes (PSRC1, MRE11A, MYO1E) in HCC are reported. The regulation of individual genes by methylation in hepatocarcinogenesis needs to be validated.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleGenes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling-
dc.title.alternativeGenes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling-
dc.typeArticle-
dc.citation.titleJournal of Korean Medical Science-
dc.citation.number11-
dc.citation.endPage1438-
dc.citation.startPage1428-
dc.citation.volume26-
dc.contributor.affiliatedAuthorIn-Sun Chu-
dc.contributor.alternativeName양주동-
dc.contributor.alternativeName설소영-
dc.contributor.alternativeName임선희-
dc.contributor.alternativeName김용훈-
dc.contributor.alternativeNameSun-
dc.contributor.alternativeName이주석-
dc.contributor.alternativeNameThorgeirsson-
dc.contributor.alternativeName추인선-
dc.contributor.alternativeNameRoberts-
dc.contributor.alternativeName강구정-
dc.identifier.bibliographicCitationJournal of Korean Medical Science, vol. 26, no. 11, pp. 1428-1438-
dc.identifier.doi10.3346/jkms.2011.26.11.1428-
dc.subject.keywordCarcinoma-
dc.subject.keywordDNA methylation-
dc.subject.keywordGene expression profiling-
dc.subject.keywordHepatocellular-
dc.subject.keywordMicroarray analysis-
dc.subject.keywordSurvival-
dc.subject.localCarcinoma-
dc.subject.localcarcinoma-
dc.subject.localDNA methylation-
dc.subject.localDNAmethylation-
dc.subject.localGene expression profiling.-
dc.subject.localGene expression profiling-
dc.subject.localgene expression profiling-
dc.subject.localHepatocellular-
dc.subject.localhepatocellular-
dc.subject.localmicroarray analysis-
dc.subject.localMicroarray analysis-
dc.subject.localsurvival-
dc.subject.localSurvival-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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