Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression = 부탐벤의 골형성 효과

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dc.contributor.authorH J Kim-
dc.contributor.authorM Park-
dc.contributor.authorY M Han-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorS H Kim-
dc.date.accessioned2017-04-19T09:26:00Z-
dc.date.available2017-04-19T09:26:00Z-
dc.date.issued2011-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2011.10.020ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10419-
dc.description.abstractAs the primary step for 'drug repositioning', we evaluated the effect of 2000 drugs and drug candidates on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the presence of bone morphogenetic protein (BMP)-2 and found that butamben enhanced BMP-2-stimulated induction of alkaline phosphatase, a biomarker of osteoblastogenesis. Investigating the underlying mechanism of its anabolic actions, we found anabolic action of its derivative (compound 4) relies on BMP-2 signaling and mRNA induction of BMPs and voltage-gated potassium channels.-
dc.publisherElsevier-
dc.titleButamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression = 부탐벤의 골형성 효과-
dc.title.alternativeButamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number24-
dc.citation.endPage7366-
dc.citation.startPage7363-
dc.citation.volume21-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName김혜주-
dc.contributor.alternativeName박미경-
dc.contributor.alternativeName한영민-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName김성환-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 21, no. 24, pp. 7363-7366-
dc.identifier.doi10.1016/j.bmcl.2011.10.020-
dc.subject.keywordBone morphogenetic protein-
dc.subject.keywordButamben-
dc.subject.keywordDrug repositioning-
dc.subject.keywordOsteoblastogenesis-
dc.subject.keywordVoltage-gated potassium channel-
dc.subject.localBone morphogenetic protein-
dc.subject.localBONE MORPHOGENETIC PROTEIN (BMP)-
dc.subject.localbone morphogenic protein-
dc.subject.localButamben-
dc.subject.localDrug repositioning-
dc.subject.localDrug Repositioning-
dc.subject.localOsteoblastogenesis-
dc.subject.localVoltage-gated potassium channel-
dc.description.journalClassY-
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