Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression = 부탐벤의 골형성 효과
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | H J Kim | - |
| dc.contributor.author | M Park | - |
| dc.contributor.author | Y M Han | - |
| dc.contributor.author | Byoung-Mog Kwon | - |
| dc.contributor.author | S H Kim | - |
| dc.date.accessioned | 2017-04-19T09:26:00Z | - |
| dc.date.available | 2017-04-19T09:26:00Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | 10.1016/j.bmcl.2011.10.020 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10419 | - |
| dc.description.abstract | As the primary step for 'drug repositioning', we evaluated the effect of 2000 drugs and drug candidates on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the presence of bone morphogenetic protein (BMP)-2 and found that butamben enhanced BMP-2-stimulated induction of alkaline phosphatase, a biomarker of osteoblastogenesis. Investigating the underlying mechanism of its anabolic actions, we found anabolic action of its derivative (compound 4) relies on BMP-2 signaling and mRNA induction of BMPs and voltage-gated potassium channels. | - |
| dc.publisher | Elsevier | - |
| dc.title | Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression = 부탐벤의 골형성 효과 | - |
| dc.title.alternative | Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
| dc.citation.number | 24 | - |
| dc.citation.endPage | 7366 | - |
| dc.citation.startPage | 7363 | - |
| dc.citation.volume | 21 | - |
| dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
| dc.contributor.alternativeName | 김혜주 | - |
| dc.contributor.alternativeName | 박미경 | - |
| dc.contributor.alternativeName | 한영민 | - |
| dc.contributor.alternativeName | 권병목 | - |
| dc.contributor.alternativeName | 김성환 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 24, pp. 7363-7366 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2011.10.020 | - |
| dc.subject.keyword | Bone morphogenetic protein | - |
| dc.subject.keyword | Butamben | - |
| dc.subject.keyword | Drug repositioning | - |
| dc.subject.keyword | Osteoblastogenesis | - |
| dc.subject.keyword | Voltage-gated potassium channel | - |
| dc.subject.local | Bone morphogenetic protein | - |
| dc.subject.local | BONE MORPHOGENETIC PROTEIN (BMP) | - |
| dc.subject.local | bone morphogenic protein | - |
| dc.subject.local | Butamben | - |
| dc.subject.local | Drug repositioning | - |
| dc.subject.local | Drug Repositioning | - |
| dc.subject.local | Osteoblastogenesis | - |
| dc.subject.local | Voltage-gated potassium channel | - |
| dc.description.journalClass | Y | - |
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