Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Human Acyl-CoA:cholesterol acyltransferase (hACAT)-inhibiting triterpenes from Lythrum salicaria L.
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- Title
- Human Acyl-CoA:cholesterol acyltransferase (hACAT)-inhibiting triterpenes from Lythrum salicaria L.
- Author(s)
- G S Kim; S E Lee; Tae Sook Jeong; C G Park; J S Sung; J B Kim; Y P Hong; Y C Kim; K S Song
- Bibliographic Citation
- Journal of Korean Society for Applied Biological Chemistry, vol. 54, no. 4, pp. 628-632
- Publication Year
- 2011
- Abstract
- β-Sitosterol (1), betulinic acid (2), and 3β-hydroxy-20(29)-lupen-28-oic acid methyl ester (3) were isolated from the herbal parts of Lythrum salicaria. Compounds 2 and 3 were isolated for the first time from L. salicaria and they showed inhibitory activities on both hACAT1 and hACAT2. These results suggested that L. salicaria, which contains triterpenes 2 and 3, might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis due to its inhibitory effect on hACAT.
- ISSN
- I000-0171
- Publisher
- Korea Soc-Assoc-Inst
- Full Text Link
- http://dx.doi.org/10.3839/jksabc.2011.095
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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