Human Acyl-CoA:cholesterol acyltransferase (hACAT)-inhibiting triterpenes from Lythrum salicaria L.

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Title
Human Acyl-CoA:cholesterol acyltransferase (hACAT)-inhibiting triterpenes from Lythrum salicaria L.
Author(s)
G S Kim; S E Lee; Tae Sook Jeong; C G Park; J S Sung; J B Kim; Y P Hong; Y C Kim; K S Song
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 54, no. 4, pp. 628-632
Publication Year
2011
Abstract
β-Sitosterol (1), betulinic acid (2), and 3β-hydroxy-20(29)-lupen-28-oic acid methyl ester (3) were isolated from the herbal parts of Lythrum salicaria. Compounds 2 and 3 were isolated for the first time from L. salicaria and they showed inhibitory activities on both hACAT1 and hACAT2. These results suggested that L. salicaria, which contains triterpenes 2 and 3, might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis due to its inhibitory effect on hACAT.
Keyword
betulinic acidbetulinic acid methyl esterLythrum salicariapurple loosestrifeβ-sitosterol
ISSN
I000-0171
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jksabc.2011.095
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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