Cug2 is essential for normal mitotic control and CNS develpment in zebrafish = 제브라피쉬의 중추신경계 발생과 정상적 유사분열 조절에 필수 인자인 Cug2

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Title
Cug2 is essential for normal mitotic control and CNS develpment in zebrafish = 제브라피쉬의 중추신경계 발생과 정상적 유사분열 조절에 필수 인자인 Cug2
Author(s)
H T Kim; J H So; S H Jung; D G Ahn; W Koh; Nam-Soon Kim; S H Kim; S Lee; C H Kim
Bibliographic Citation
BMC Developmental Biology, vol. 11, pp. 49-49
Publication Year
2011
Abstract
Background: We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has not been studied in animal models. Results: To study the function of CUG2 in vivo, we isolated a zebrafish homologue that is expressed specifically in the proliferating cells of the central nervous system (CNS). Morpholino-mediated knockdown of cug2 resulted in apoptosis throughout the CNS and the development of neurodegenerative phenotypes. In addition, cug2-deficient embryos contained mitotically arrested cells displaying abnormal spindle formation and chromosome misalignment in the neural plate. Conclusions: Therefore, our findings suggest that Cug2 is required for normal mitosis during early neurogenesis and has functions in neuronal cell maintenance, thus demonstrating that the cug2 deficient embryos may provide a model system for human neurodegenerative disorders.
ISSN
1471-213X
Publisher
Springer-BMC
DOI
http://dx.doi.org/10.1186/1471-213X-11-49
Type
Article
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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