Production of 3-hydroxypropionic acid through propionaldehyde dehydrogenase PduP mediated biosynthetic pathway in Klebsiella penumoniae

Cited 41 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorL H Luo-
dc.contributor.authorChul Ho Kim-
dc.contributor.authorSun-Yeon Heo-
dc.contributor.authorBaek Rock Oh-
dc.contributor.authorWon Kyung Hong-
dc.contributor.authorSeonghun Kim-
dc.contributor.authorD H Kim-
dc.contributor.authorJeong-Woo Seo-
dc.date.accessioned2017-04-19T09:26:21Z-
dc.date.available2017-04-19T09:26:21Z-
dc.date.issued2012-
dc.identifier.issn0960-8524-
dc.identifier.uri10.1016/j.biortech.2011.09.099ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10434-
dc.description.abstractThe pduP gene encodes a propionaldehyde dehydrogenase (PduP) was investigated for the role in 3-hydroxypropionic acid (3-HP) glycerol metabolism in Klebsiella pneumoniae. The enzyme assay showed that cell extracts from a pduP mutant strain lacked measurable dehydrogenase activity. Additionally, the mutant strain accumulated the cytotoxic intermediate metabolite 3-hydroxypropionaldehyde (3-HPA), causing both cell death and a lower final 3-HP titer. Ectopic expression of pduP restored normal cell growth to mutant. The enzymatic property of recombinant protein from Escherichia coli was examined, exhibiting a broad substrate specificity, being active on 3-HPA. The present work is thus the first to demonstrate the role of PduP in glycerol metabolism and biosynthesis of 3-HP.-
dc.publisherElsevier-
dc.titleProduction of 3-hydroxypropionic acid through propionaldehyde dehydrogenase PduP mediated biosynthetic pathway in Klebsiella penumoniae-
dc.title.alternativeProduction of 3-hydroxypropionic acid through propionaldehyde dehydrogenase PduP mediated biosynthetic pathway in Klebsiella penumoniae-
dc.typeArticle-
dc.citation.titleBioresource Technology-
dc.citation.number1-
dc.citation.endPage6-
dc.citation.startPage1-
dc.citation.volume103-
dc.contributor.affiliatedAuthorChul Ho Kim-
dc.contributor.affiliatedAuthorSun-Yeon Heo-
dc.contributor.affiliatedAuthorBaek Rock Oh-
dc.contributor.affiliatedAuthorWon Kyung Hong-
dc.contributor.affiliatedAuthorSeonghun Kim-
dc.contributor.affiliatedAuthorJeong-Woo Seo-
dc.contributor.alternativeNameLuo-
dc.contributor.alternativeName김철호-
dc.contributor.alternativeName허선연-
dc.contributor.alternativeName오백록-
dc.contributor.alternativeName홍원경-
dc.contributor.alternativeName김성훈-
dc.contributor.alternativeName김대혁-
dc.contributor.alternativeName서정우-
dc.identifier.bibliographicCitationBioresource Technology, vol. 103, no. 1, pp. 1-6-
dc.identifier.doi10.1016/j.biortech.2011.09.099-
dc.subject.keyword3-hydroxypropionic acid-
dc.subject.keywordGlycerol-
dc.subject.keywordKlebsiella pneumoniae-
dc.subject.keywordPropanediol utilization protein-
dc.subject.keywordPropionaldehyde dehydrogenase-
dc.subject.local3-Hydroxypropionic acid-
dc.subject.local3-hydroxypropionic acid-
dc.subject.localGlycerol-
dc.subject.localglycerol-
dc.subject.localKlebsiella pneumonia-
dc.subject.localKlebsiella pneumoniae-
dc.subject.localPropanediol utilization protein PduP-
dc.subject.localPropanediol utilization protein-
dc.subject.localPropionaldehyde dehydrogenase-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.