Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancer growth via nuclear factor-kB and is associated with poor patient outcome

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Title
Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancer growth via nuclear factor-kB and is associated with poor patient outcome
Author(s)
Oh Hyung Kwon; Seong Joon Park; Tae-Wook Kang; Mirang KimJeong Hwan Kim; S M Noh; K S Song; Hyang Sook Yoo; Y Wang; D Pocalyko; S G Paik; Y H Kim; Seon-Young Kim; Yong Sung Kim
Bibliographic Citation
Cancer Letters, vol. 314, no. 1, pp. 73-81
Publication Year
2012
Abstract
The fibroblast growth factor-inducible 14 (Fn14) gene encodes a type I transmembrane protein that belongs to the tumor necrosis factor receptor superfamily and regulates multiple cellular processes in diverse physiological and pathological conditions, including cancer. Here, we describe an important role for Fn14 in regulating the growth of gastric cancer cells. Previous gene expression data analysis demonstrated that Fn14 was up-regulated in various tumor tissues, including gastric cancer. Using qRT-PCR, we showed that Fn14 was overexpressed in gastric tumor tissues compared to normal tissues. Furthermore, Fn14 expression levels were inversely correlated with gastric cancer patient survival. Using ectopic overexpression and shRNA-mediated knockdown of Fn14, we demonstrated that the expression level of Fn14 affected cell growth in gastric cancer. The effect of Fn14 on cell growth was mediated by the NF-κB activity and eventually by the transcriptional regulation of the anti-apoptotic Bcl-2 family gene (Bcl-xL). These results suggest that Fn14 may play an important role in gastric tumor growth by regulating NF-κB-mediated anti-apoptosis and that Fn14 may be a useful prognostic marker for gastric cancer.
Keyword
Anti-apoptosisCell growthFn14Gastric cancerNF-κB
ISSN
0304-3835
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.canlet.2011.09.016
Type
Article
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
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