Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell

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dc.contributor.authorJihoon Kim-
dc.contributor.authorYu Jin Lee-
dc.contributor.authorD S Shin-
dc.contributor.authorS H Jeon-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorDong Cho Han-
dc.contributor.authorSeung Nam Jung-
dc.contributor.authorTae Kwang Oh-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T09:26:22Z-
dc.date.available2017-04-19T09:26:22Z-
dc.date.issued2011-
dc.identifier.issn0968-0896-
dc.identifier.uri10.1016/j.bmc.2011.10.025ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10438-
dc.description.abstractThe signal transducer and activator of transcription 3 (STAT3) is constitutively activated in cancer cells. Therefore, blocking the aberrant activity of STAT3 in tumor cells is a validated therapeutic strategy. To discover novel inhibitors of STAT3 activity, we screened against microbial natural products using a dual-luciferase assay. Using the microbial metabolome library, we identified cosmomycin C (CosC), which was isolated from the mycelium extract of Streptomyces sp. KCTC19769, as a STAT3 pathway inhibitor. CosC inhibited STAT3 (Tyr705) phosphorylation and subsequent nuclear translocation in MDA-MB-468 breast cancer cells. CosC-mediated inhibition of STAT3 signaling pathway was confirmed by suppressed expression of STAT3 downstream target proteins including cyclin D1, Bcl-xL, survivin, Mcl-1, and VEGF in CosC-treated MDA-MB-468 cells. Flow cytometry showed that CosC caused accumulation in the G0-G1 phase of the cell cycle and induced apoptosis via PARP cleavage and caspase-3 activation. Based on these findings, CosC may be a potential candidate for modulation of STAT3 pathway.-
dc.publisherElsevier-
dc.titleCosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell-
dc.title.alternativeCosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number24-
dc.citation.endPage7589-
dc.citation.startPage7582-
dc.citation.volume19-
dc.contributor.affiliatedAuthorJihoon Kim-
dc.contributor.affiliatedAuthorYu Jin Lee-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.affiliatedAuthorSeung Nam Jung-
dc.contributor.affiliatedAuthorTae Kwang Oh-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName김지훈-
dc.contributor.alternativeName이유진-
dc.contributor.alternativeName신대섭-
dc.contributor.alternativeName전선희-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName한동초-
dc.contributor.alternativeName정승남-
dc.contributor.alternativeName오태광-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 19, no. 24, pp. 7582-7589-
dc.identifier.doi10.1016/j.bmc.2011.10.025-
dc.subject.keywordAntitumor-
dc.subject.keywordApoptosis-
dc.subject.keywordBreast cancer-
dc.subject.keywordCosmomycin-
dc.subject.keywordSignal transducer and activator of transcription 3 (STAT3)-
dc.subject.localAnti-tumor-
dc.subject.localantitumor-
dc.subject.localAntitumor-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localbreast cancer-
dc.subject.localBreast cancer-
dc.subject.localBreast Cancer-
dc.subject.localCosmomycin-
dc.subject.localSignal transducer and activator of transcription 3 (STAT3)-
dc.subject.localSignal transducer and activator of transcription-
dc.subject.localSignal transducer and activator of transcription 3 (Stat3)-
dc.subject.localSTAT 3-
dc.subject.localSTAT3-
dc.subject.localSignal transducer and activator of transcription 3-
dc.subject.localStat3-
dc.subject.localSignal transducer and activator of transcription factor 3 (STAT3)-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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