DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jihoon Kim | - |
dc.contributor.author | Yu Jin Lee | - |
dc.contributor.author | D S Shin | - |
dc.contributor.author | S H Jeon | - |
dc.contributor.author | Kwang Hee Son | - |
dc.contributor.author | Dong Cho Han | - |
dc.contributor.author | Seung Nam Jung | - |
dc.contributor.author | Tae Kwang Oh | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.date.accessioned | 2017-04-19T09:26:22Z | - |
dc.date.available | 2017-04-19T09:26:22Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | 10.1016/j.bmc.2011.10.025 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10438 | - |
dc.description.abstract | The signal transducer and activator of transcription 3 (STAT3) is constitutively activated in cancer cells. Therefore, blocking the aberrant activity of STAT3 in tumor cells is a validated therapeutic strategy. To discover novel inhibitors of STAT3 activity, we screened against microbial natural products using a dual-luciferase assay. Using the microbial metabolome library, we identified cosmomycin C (CosC), which was isolated from the mycelium extract of Streptomyces sp. KCTC19769, as a STAT3 pathway inhibitor. CosC inhibited STAT3 (Tyr705) phosphorylation and subsequent nuclear translocation in MDA-MB-468 breast cancer cells. CosC-mediated inhibition of STAT3 signaling pathway was confirmed by suppressed expression of STAT3 downstream target proteins including cyclin D1, Bcl-xL, survivin, Mcl-1, and VEGF in CosC-treated MDA-MB-468 cells. Flow cytometry showed that CosC caused accumulation in the G0-G1 phase of the cell cycle and induced apoptosis via PARP cleavage and caspase-3 activation. Based on these findings, CosC may be a potential candidate for modulation of STAT3 pathway. | - |
dc.publisher | Elsevier | - |
dc.title | Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell | - |
dc.title.alternative | Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry | - |
dc.citation.number | 24 | - |
dc.citation.endPage | 7589 | - |
dc.citation.startPage | 7582 | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Jihoon Kim | - |
dc.contributor.affiliatedAuthor | Yu Jin Lee | - |
dc.contributor.affiliatedAuthor | Kwang Hee Son | - |
dc.contributor.affiliatedAuthor | Dong Cho Han | - |
dc.contributor.affiliatedAuthor | Seung Nam Jung | - |
dc.contributor.affiliatedAuthor | Tae Kwang Oh | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 김지훈 | - |
dc.contributor.alternativeName | 이유진 | - |
dc.contributor.alternativeName | 신대섭 | - |
dc.contributor.alternativeName | 전선희 | - |
dc.contributor.alternativeName | 손광희 | - |
dc.contributor.alternativeName | 한동초 | - |
dc.contributor.alternativeName | 정승남 | - |
dc.contributor.alternativeName | 오태광 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, vol. 19, no. 24, pp. 7582-7589 | - |
dc.identifier.doi | 10.1016/j.bmc.2011.10.025 | - |
dc.subject.keyword | Antitumor | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Cosmomycin | - |
dc.subject.keyword | Signal transducer and activator of transcription 3 (STAT3) | - |
dc.subject.local | Anti-tumor | - |
dc.subject.local | antitumor | - |
dc.subject.local | Antitumor | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.subject.local | breast cancer | - |
dc.subject.local | Breast cancer | - |
dc.subject.local | Breast Cancer | - |
dc.subject.local | Cosmomycin | - |
dc.subject.local | Signal transducer and activator of transcription 3 (STAT3) | - |
dc.subject.local | Signal transducer and activator of transcription | - |
dc.subject.local | Signal transducer and activator of transcription 3 (Stat3) | - |
dc.subject.local | STAT 3 | - |
dc.subject.local | STAT3 | - |
dc.subject.local | Signal transducer and activator of transcription 3 | - |
dc.subject.local | Stat3 | - |
dc.subject.local | Signal transducer and activator of transcription factor 3 (STAT3) | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.