Antiatherogenic effect of antioxidant polyphenols from Phellinus baumii in apolipoprotein E-deficient mice

Cited 11 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJung Ran Noh-
dc.contributor.authorI K Lee-
dc.contributor.authorYong Hoon Kim-
dc.contributor.authorGil Tae Gang-
dc.contributor.authorJung Hwan Hwang-
dc.contributor.authorS Y Ly-
dc.contributor.authorB S Yun-
dc.contributor.authorChul Ho Lee-
dc.date.accessioned2017-04-19T09:26:44Z-
dc.date.available2017-04-19T09:26:44Z-
dc.date.issued2011-
dc.identifier.issn0250-6807-
dc.identifier.uri10.1159/000334264ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10455-
dc.description.abstractAims: The present study was carried out to investigate the antiatherosclerotic effect of antioxidant polyphenols from Phellinus baumii (PBE) in apolipoprotein E-deficient (apoE-/-) mice. Methods and Results: apoE-/- mice were randomly divided into three groups: mice on a normal chow diet comprised the normal group, mice on an atherogenic diet plus vehicle were the control group, and mice on an atherogenic diet plus PBE (500 mg/kg) comprised the PB500 group. After 8 weeks of treatment, the plasma lipids and cytokine levels were measured. Although no significant differences were found in cholesterol levels among groups, the triglyceride level was significantly decreased in the PBE-treated group compared with the control group. Plasma tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were reduced by PBE treatment. Real-time PCR analysis of the aorta showed that PBE significantly prevented the upregulation of the vascular cell adhesion molecule (VCAM)-1, intercellular adhesion molecule (ICAM)-1, TNF-α, IL-6, and IL-1β expression. Furthermore, reduced macrophage infiltration, lipid accumulation and atherosclerotic lesions were observed in the aortic sinus and en face of the whole aorta in PBE-fed apoE-/- mice compared with atherogenic diet-fed control mice. Conclusions: Collectively, the findings of the present study suggest that the antiatherosclerotic effect of PBE is probably related to the inhibition of adhesion molecule and cytokine expression resulting in amelioration of lesion development.-
dc.publisherKarger-
dc.titleAntiatherogenic effect of antioxidant polyphenols from Phellinus baumii in apolipoprotein E-deficient mice-
dc.title.alternativeAntiatherogenic effect of antioxidant polyphenols from Phellinus baumii in apolipoprotein E-deficient mice-
dc.typeArticle-
dc.citation.titleAnnals of Nutrition and Metabolism-
dc.citation.number2-
dc.citation.endPage153-
dc.citation.startPage145-
dc.citation.volume59-
dc.contributor.affiliatedAuthorJung Ran Noh-
dc.contributor.affiliatedAuthorYong Hoon Kim-
dc.contributor.affiliatedAuthorGil Tae Gang-
dc.contributor.affiliatedAuthorJung Hwan Hwang-
dc.contributor.affiliatedAuthorChul Ho Lee-
dc.contributor.alternativeName노정란-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName김용훈-
dc.contributor.alternativeName강길태-
dc.contributor.alternativeName황정환-
dc.contributor.alternativeNameLy-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName이철호-
dc.identifier.bibliographicCitationAnnals of Nutrition and Metabolism, vol. 59, no. 2, pp. 145-153-
dc.identifier.doi10.1159/000334264-
dc.subject.keywordAdhesion molecule-
dc.subject.keywordAntioxidant polyphenols-
dc.subject.keywordApolipoprotein E-deficient mice-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordPhellinus baumii-
dc.subject.localadhesion molecules-
dc.subject.localadhesion molecule-
dc.subject.localAdhesion molecule-
dc.subject.localAntioxidant polyphenols-
dc.subject.localApolipoprotein E-deficient mice-
dc.subject.localatherosclerosis-
dc.subject.localAtherosclerosis-
dc.subject.localatheroclerosis-
dc.subject.localPhellinus baumii-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.