Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

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Title
Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects
Author(s)
Y T Lim; Sang-Moo Shim; Y W Noh; K S Lee; D Y Choi; H Uyama; H H Bae; J H Kim; K S Hong; M H Sung; Haryoung Poo
Bibliographic Citation
Small, vol. 7, no. 23, pp. 3281-3286
Publication Year
2011
Abstract
An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.
Keyword
antigensdendritic cellsdrug deliverypolyelectrolyte nanogelsvaccine adjuvant
ISSN
1613-6810
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/smll.201101836
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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