Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells = 갱글리오사이드의 GQ1b에 의해 마우스 줄기세포에서 신경세포로의 분화를 조절

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dc.contributor.authorD H Kwak-
dc.contributor.authorJ W Jin-
dc.contributor.authorJ S Ryu-
dc.contributor.authorK Ko-
dc.contributor.authorS D Lee-
dc.contributor.authorJeong Woong Lee-
dc.contributor.authorJi Su Kim-
dc.contributor.authorK Y Jung-
dc.contributor.authorK Ko-
dc.contributor.authorJ Y Ma-
dc.contributor.authorK A Hwang-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorY K Choo-
dc.date.accessioned2017-04-19T09:27:21Z-
dc.date.available2017-04-19T09:27:21Z-
dc.date.issued2011-
dc.identifier.issn1225-8687-
dc.identifier.uri10.5483/BMBRep.2011.44.12.799ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10461-
dc.description.abstractGangliosides play an important role in neuronal differentiation processes. The regulation of ganglioside levels is related to the induction of neuronal cell differentiation. In this study, the ST8Sia5 gene was transfected into mESCs and then differentiated into neuronal cells. Interestingly, ST8Sia5 gene transfected mESCs expressed GQ1b by HPTLC and immunofluorescence analysis. To investigate the effects of GQ1b over-expression in neurogenesis, neuronal cells were differentiated from GQ1b expressing mESCs in the presence of retinoic acid. In GQ1b expressing mESCs, increased EBs formation was observed. After 4 days, EBs were co-localized with GQ1b and nestin, and GFAP. Moreover, GQ1b co-localized with MAP-2 expressing cells in GQ1b expressing mESCs in 7-day-old EBs. Furthermore, GQ1b expressing mESCs increased the ERK1/2 MAP kinase pathway. These results suggest that the ST8Sia5 gene increases ganglioside GQ1b and improves neuronal differentiation via the ERK1/2 MAP kinase pathway.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRegulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells = 갱글리오사이드의 GQ1b에 의해 마우스 줄기세포에서 신경세포로의 분화를 조절-
dc.title.alternativeRegulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number12-
dc.citation.endPage804-
dc.citation.startPage799-
dc.citation.volume44-
dc.contributor.affiliatedAuthorJeong Woong Lee-
dc.contributor.affiliatedAuthorJi Su Kim-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName곽동훈-
dc.contributor.alternativeName진정우-
dc.contributor.alternativeName류재성-
dc.contributor.alternativeName고기남-
dc.contributor.alternativeName이소담-
dc.contributor.alternativeName이정웅-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName정규용-
dc.contributor.alternativeName고기성-
dc.contributor.alternativeName마진열-
dc.contributor.alternativeName황경아-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName추영국-
dc.identifier.bibliographicCitationBMB Reports, vol. 44, no. 12, pp. 799-804-
dc.identifier.doi10.5483/BMBRep.2011.44.12.799-
dc.subject.keyword8-sialyltransferase 5 (ST8Sia5)-
dc.subject.keywordGanglioside GQ1b-
dc.subject.keywordMAP kinase-
dc.subject.keywordMouse embryonic stem cells (mESCs)-
dc.subject.keywordNeuronal differentiation-
dc.subject.keywordST8 alpha-N-acetyl-neuraminidase alpha-2-
dc.subject.local8-sialyltransferase 5 (ST8Sia5)-
dc.subject.localGanglioside GQ1b-
dc.subject.localMAP kinases-
dc.subject.localmap kinase-
dc.subject.localMAP kinase-
dc.subject.localMouse embryonic stem cells (mESCs)-
dc.subject.localMouse embryonic stem cells-
dc.subject.localNeuronal differentiation-
dc.subject.localneuronal differentiation-
dc.subject.localST8 alpha-N-acetyl-neuraminidase alpha-2-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
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