Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury

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dc.contributor.authorS Park-
dc.contributor.authorS K Lee-
dc.contributor.authorK Park-
dc.contributor.authorYoungjeon Lee-
dc.contributor.authorY Hong-
dc.contributor.authorS Lee-
dc.contributor.authorJ C Jeon-
dc.contributor.authorJ H Kim-
dc.contributor.authorSang Rae Lee-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorY Hong-
dc.date.accessioned2017-04-19T09:27:22Z-
dc.date.available2017-04-19T09:27:22Z-
dc.date.issued2012-
dc.identifier.issn0742-3098-
dc.identifier.uri10.1111/j.1600-079X.2011.00925.xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10471-
dc.description.abstractThe purpose of this study was to investigate the beneficial effects of endogenous and exogenous melatonin on functional recovery in an animal model of spinal cord injury (SCI). Eight-week-old male Sprague-Dawley (SD, 250-260 g) rats were used for contusion SCI surgery. All experimental groups were maintained under one of the following conditions: 12/12-hr light/dark (L/D) or 24:0-hr constant light (LL). Melatonin (10 mg/kg) was injected subcutaneously for 4 wk, twice daily (07:00, 19:00). Locomotor recovery, inducible nitric oxide synthase (iNOS), glial fibrillary acidic protein gene expression, and muscle atrophy-related genes, including muscle atrophy F-box (MAFbx) and muscle-specific ring-finger protein 1 (MuRF1) gene expression were evaluated. Furthermore, autophagic signaling such as Beclin-1 and LC3 protein expression was examined in the spinal cord and in skeletal muscle. The melatonin treatment resulted in increased hind-limb motor function and decreased iNOS mRNA expression in the L/D condition compared with the LL condition (P < 0.05), indicating that endogenous melatonin had neuroprotective effects. Furthermore, the MAFbx, MuRF1 mRNA level, and converted LC3 II protein expression were decreased in the melatonin-treated SCI groups under the LL (P < 0.05), possibly in response to the exogenous melatonin treatment. Therefore, it seems that both endogenous and exogenous melatonin contribute to neural recovery and to the prevention of skeletal muscle atrophy, promoting functional recovery after SCI. Finally, this study supports the benefit of endogenous melatonin and use of exogenous melatonin as a therapeutic intervention for SCI.-
dc.publisherWiley-
dc.titleBeneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury-
dc.title.alternativeBeneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury-
dc.typeArticle-
dc.citation.titleJournal of Pineal Research-
dc.citation.number1-
dc.citation.endPage119-
dc.citation.startPage107-
dc.citation.volume52-
dc.contributor.affiliatedAuthorYoungjeon Lee-
dc.contributor.affiliatedAuthorSang Rae Lee-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.affiliatedAuthorY Hong-
dc.contributor.alternativeName박수경-
dc.contributor.alternativeName이상길-
dc.contributor.alternativeName박강희-
dc.contributor.alternativeName이영전-
dc.contributor.alternativeName홍윤경-
dc.contributor.alternativeName이승훈-
dc.contributor.alternativeName전제철-
dc.contributor.alternativeName김주헌-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName홍용근-
dc.identifier.bibliographicCitationJournal of Pineal Research, vol. 52, no. 1, pp. 107-119-
dc.identifier.doi10.1111/j.1600-079X.2011.00925.x-
dc.subject.keywordatrogenes-
dc.subject.keywordautophagy-
dc.subject.keywordendogenous and exogenous melatonin-
dc.subject.keywordfunctional recovery-
dc.subject.keywordglial fibrillary acidic protein-
dc.subject.keywordinducible nitric oxide synthase-
dc.subject.keywordspinal cord injury-
dc.subject.localatrogenes-
dc.subject.localautophagy-
dc.subject.localAutophagy-
dc.subject.localendogenous and exogenous melatonin-
dc.subject.localFunctional recovery-
dc.subject.localfunctional recovery-
dc.subject.localglial fibrillary acidic protein-
dc.subject.localInducible nitric oxide synthase (iNOS)-
dc.subject.localInducible nitric oxide synthase-
dc.subject.localinducible nnitric oxide synthase-
dc.subject.localiNOS-
dc.subject.localInducible nitric oxide synthease (iNOS)-
dc.subject.localINOS-
dc.subject.localinducible nitric oxide synthase-
dc.subject.localSpinal cord injury (SCI)-
dc.subject.localspinal cord injury-
dc.subject.localSpinal cord injury-
dc.subject.localspinal cord injury (SCI)-
dc.description.journalClassY-
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Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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