Assessment of reactive metabolites in drug-induced liver injury

Cited 11 time in scopus
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dc.contributor.authorK S Lee-
dc.contributor.authorSoo Jin Oh-
dc.contributor.authorH M Kim-
dc.contributor.authorK H Lee-
dc.contributor.authorS K Kim-
dc.date.accessioned2017-04-19T09:27:30Z-
dc.date.available2017-04-19T09:27:30Z-
dc.date.issued2011-
dc.identifier.issn02536269-
dc.identifier.uri10.1007/s12272-011-1108-xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10491-
dc.description.abstractThe aim of the current review is to summarize present methods used for the determination of reactive metabolites, which can predict drug-induced liver injury (DILI) in drug discovery and development. DILI is one of the most frequent reasons for the withdrawal of an approved drug from the market, and it accounts for up to 50% of acute liver failure cases. This review is structured into three sections. The first section is a general overview of the relationship between drug metabolism and liver injury. The second section introduces in vitro methods for the assessment of reactive metabolites for drug discovery and development. In the third section, limitations and future directions for the development of methods for predicting DILI are described.-
dc.publisherPharmaceutical Soc Korea-
dc.titleAssessment of reactive metabolites in drug-induced liver injury-
dc.title.alternativeAssessment of reactive metabolites in drug-induced liver injury-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number11-
dc.citation.endPage1886-
dc.citation.startPage1879-
dc.citation.volume34-
dc.contributor.alternativeName이계숙-
dc.contributor.alternativeName오수진-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName김상겸-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 34, no. 11, pp. 1879-1886-
dc.identifier.doi10.1007/s12272-011-1108-x-
dc.subject.keywordAcyl glucuronide-
dc.subject.keywordDrug metabolism-
dc.subject.keywordDrug-induced liver injury-
dc.subject.keywordMechanism-based inhibition-
dc.subject.keywordReactive metabolites-
dc.subject.localAcyl glucuronide-
dc.subject.localDrug metabolism-
dc.subject.localDrug-induced liver injury-
dc.subject.localMechanism-based inhibition-
dc.subject.localReactive metabolites-
dc.description.journalClassY-
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