FPTase inhibition effect of protostanes from Alismatis Rhizoma and derivatives from alisol B 23-acetate = 택사(Alismatis Rhizoma)에서 분리한 Protostane계 화합물과 그 유도체의 FPTase 억제활성

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Title
FPTase inhibition effect of protostanes from Alismatis Rhizoma and derivatives from alisol B 23-acetate = 택사(Alismatis Rhizoma)에서 분리한 Protostane계 화합물과 그 유도체의 FPTase 억제활성
Author(s)
S M Lee; Byoung-Mog Kwon; M S Min
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 42, no. 3, pp. 218-222
Publication Year
2011
Abstract
The purpose of this research is to study of inhibitory activity of protostane type triterpens against farnesyl-protein transferase (FPTase). The ingredients of Alismatis Rhizoma, alisol B 23-acetate, C 23-acetate, alisols B and A 24-acetate, and thirteen synthetic analogues from alisol B 23-acetate exhibited inhibition activity against FPTase by scintillation proximity assay method. As a result, alisol C 23-acetate, one of the constituents of Alismatis Rhizoma, the synthetic analogues carboxylated and hydroxylated on branch chain of protostane exhibited a significant inhibitory activity. However, the compounds significantly lowered the inhibitory activity, when there is no 3 position keto on protostane skeletone.
Keyword
Alismatis RhizomaAlisolFarnesyl-protein transferase (FPTase)
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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