L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells

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dc.contributor.authorHyunho Yoon-
dc.contributor.authorJeong Ki Min-
dc.contributor.authorDong Gwang Lee-
dc.contributor.authorD G Kim-
dc.contributor.authorSang Seok Koh-
dc.contributor.authorH J Hong-
dc.date.accessioned2017-04-19T09:27:34Z-
dc.date.available2017-04-19T09:27:34Z-
dc.date.issued2012-
dc.identifier.issn0304-3835-
dc.identifier.uri10.1016/j.canlet.2011.10.024ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10501-
dc.description.abstractIntrahepatic cholangiocarcinoma (ICC) is refractory to conventional chemotherapy. We previously generated chemoresistant ICC (SCK R) cells and showed that AKT and ERK signaling conferred cisplatin resistance. Here, we report that epidermal growth factor receptor (EGFR) signaling and L1 cell adhesion molecule (L1CAM) conferred cisplatin resistance in SCK R cells in an additive fashion. Activation of EGFR connected to AKT and ERK signaling pathways may induce anti-apoptosis and promote cell proliferation, while L1CAM promoted cell proliferation by mainly activating ERK signaling. Inhibition of EGFR activation or L1ACM greatly sensitized the cells to cisplatin. EGFR and L1CAM may be important targets for ICC therapy.-
dc.publisherElsevier-
dc.titleL1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells-
dc.title.alternativeL1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells-
dc.typeArticle-
dc.citation.titleCancer Letters-
dc.citation.number1-
dc.citation.endPage76-
dc.citation.startPage70-
dc.citation.volume316-
dc.contributor.affiliatedAuthorHyunho Yoon-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.affiliatedAuthorDong Gwang Lee-
dc.contributor.affiliatedAuthorSang Seok Koh-
dc.contributor.alternativeName윤현호-
dc.contributor.alternativeName민정기-
dc.contributor.alternativeName이동광-
dc.contributor.alternativeName김대곤-
dc.contributor.alternativeName고상석-
dc.contributor.alternativeName홍효정-
dc.identifier.bibliographicCitationCancer Letters, vol. 316, no. 1, pp. 70-76-
dc.identifier.doi10.1016/j.canlet.2011.10.024-
dc.subject.keywordCisplatin resistance-
dc.subject.keywordEGFR-
dc.subject.keywordIntrahepatic cholangiocarcinoma-
dc.subject.keywordL1CAM-
dc.subject.localcisplatin resistance-
dc.subject.localCisplatin resistance-
dc.subject.localEGFR-
dc.subject.localIntrahepatic cholangiocarcinoma-
dc.subject.localIntrahepatic chol-angiocarcinoma-
dc.subject.localL1CAM-
dc.description.journalClassY-
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Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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