Peroxiredoxin Il is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells

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dc.contributor.authorD H Kang-
dc.contributor.authorD J Lee-
dc.contributor.authorK W Lee-
dc.contributor.authorY S Park-
dc.contributor.authorJ Y Lee-
dc.contributor.authorS H Lee-
dc.contributor.authorY J Koh-
dc.contributor.authorG Y Koh-
dc.contributor.authorC Choi-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorJ Kim-
dc.contributor.authorS W Kang-
dc.date.accessioned2017-04-19T09:28:15Z-
dc.date.available2017-04-19T09:28:15Z-
dc.date.issued2011-
dc.identifier.issn10972765-
dc.identifier.uri10.1016/j.molcel.2011.08.040ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10534-
dc.description.abstractCellular antioxidant enzymes play crucial roles in aerobic organisms by eliminating detrimental oxidants and maintaining the intracellular redox homeostasis. Therefore, the function of antioxidant enzymes is inextricably linked to the redox-dependent activities of multiple proteins and signaling pathways. Here, we report that the VEGFR2 RTK has an oxidation-sensitive cysteine residue whose reduced state is preserved specifically by peroxiredoxin II (PrxII) in vascular endothelial cells. In the absence of PrxII, the cellular H2O2 level is markedly increased and the VEGFR2 becomes inactive, no longer responding to VEGF stimulation. Such VEGFR2 inactivation is due to the formation of intramolecular disulfide linkage between Cys1199 and Cys1206 in the C-terminal tail. Interestingly, the PrxII-mediated VEGFR2 protection is achieved by association of two proteins in the caveolae. Furthermore, PrxII deficiency suppresses tumor angiogenesis in vivo. This study thus demonstrates a physiological function of PrxII as the residential antioxidant safeguard specific to the redox-sensitive VEGFR2.-
dc.publisherElsevier-Cell Press-
dc.titlePeroxiredoxin Il is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells-
dc.title.alternativePeroxiredoxin Il is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells-
dc.typeArticle-
dc.citation.titleMolecular Cell-
dc.citation.number4-
dc.citation.endPage558-
dc.citation.startPage545-
dc.citation.volume44-
dc.contributor.alternativeName강동훈-
dc.contributor.alternativeName이두재-
dc.contributor.alternativeName이경화-
dc.contributor.alternativeName박윤선-
dc.contributor.alternativeName이주영-
dc.contributor.alternativeName이상희-
dc.contributor.alternativeName고영준-
dc.contributor.alternativeName고귀영-
dc.contributor.alternativeName최철희-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName김재상-
dc.contributor.alternativeName강상원-
dc.identifier.bibliographicCitationMolecular Cell, vol. 44, no. 4, pp. 545-558-
dc.identifier.doi10.1016/j.molcel.2011.08.040-
dc.description.journalClassY-
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