Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes

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dc.contributor.authorD H Lee-
dc.contributor.authorYoura Lee-
dc.contributor.authorJoohyun Ryu-
dc.contributor.authorSung Goo Park-
dc.contributor.authorS Cho-
dc.contributor.authorJ J Lee-
dc.contributor.authorC Choi-
dc.contributor.authorByoung Chul Park-
dc.date.accessioned2017-04-19T09:28:16Z-
dc.date.available2017-04-19T09:28:16Z-
dc.date.issued2011-
dc.identifier.issn1016-8478-
dc.identifier.uri10.1007/s10059-011-1053-zko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10535-
dc.description.abstractIn a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleIdentification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes-
dc.title.alternativeIdentification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number6-
dc.citation.endPage571-
dc.citation.startPage563-
dc.citation.volume31-
dc.contributor.affiliatedAuthorYoura Lee-
dc.contributor.affiliatedAuthorJoohyun Ryu-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.alternativeName이도희-
dc.contributor.alternativeName이유라-
dc.contributor.alternativeName유주현-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName조사연-
dc.contributor.alternativeName이제정-
dc.contributor.alternativeName최찬-
dc.contributor.alternativeName박병철-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 31, no. 6, pp. 563-571-
dc.identifier.doi10.1007/s10059-011-1053-z-
dc.subject.keywordAAT-
dc.subject.keywordAGR2-
dc.subject.keywordDBP-
dc.subject.keywordgastric cancer-
dc.subject.keywordmetastasis-
dc.subject.keywordproteome-
dc.subject.localAAT-
dc.subject.localAGR2-
dc.subject.localDBP-
dc.subject.localgastric cancer-
dc.subject.localGastric cancer (GC)-
dc.subject.localGastric cancer-
dc.subject.localmetastasis-
dc.subject.localMetastasis-
dc.subject.localProteome-
dc.subject.localProteomes-
dc.subject.localproteome-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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