Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | B W Choi | - |
| dc.contributor.author | Hyun Sun Lee | - |
| dc.contributor.author | K B Lee | - |
| dc.contributor.author | B H Lee | - |
| dc.date.accessioned | 2017-04-19T09:28:16Z | - |
| dc.date.available | 2017-04-19T09:28:16Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.issn | 0951-418X | - |
| dc.identifier.uri | 10.1002/ptr.3391 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10536 | - |
| dc.description.abstract | The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC50 values of 46.0 μM and 23.3 μM, respectively. | - |
| dc.publisher | Wiley | - |
| dc.title | Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum | - |
| dc.title.alternative | Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum | - |
| dc.type | Article | - |
| dc.citation.title | Phytotherapy Research | - |
| dc.citation.number | 7 | - |
| dc.citation.endPage | 1045 | - |
| dc.citation.startPage | 1041 | - |
| dc.citation.volume | 25 | - |
| dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
| dc.contributor.alternativeName | 최병욱 | - |
| dc.contributor.alternativeName | 이현선 | - |
| dc.contributor.alternativeName | 이경복 | - |
| dc.contributor.alternativeName | 이봉호 | - |
| dc.identifier.bibliographicCitation | Phytotherapy Research, vol. 25, no. 7, pp. 1041-1045 | - |
| dc.identifier.doi | 10.1002/ptr.3391 | - |
| dc.subject.keyword | Acyl CoA:diacylglycerol acyltransferase (DGAT) | - |
| dc.subject.keyword | Hypertriglyceridemia | - |
| dc.subject.keyword | Obesity | - |
| dc.subject.keyword | Pachydictyon coriaceum | - |
| dc.subject.keyword | Terpenoids | - |
| dc.subject.keyword | Type 2 diabetes | - |
| dc.subject.local | Acyl CoA:diacylglycerol acyltransferase (DGAT) | - |
| dc.subject.local | Hypertriglyceridemia | - |
| dc.subject.local | Obesity | - |
| dc.subject.local | obesity | - |
| dc.subject.local | Pachydictyon coriaceum | - |
| dc.subject.local | Terpenoid | - |
| dc.subject.local | terpenoid | - |
| dc.subject.local | terpenoids | - |
| dc.subject.local | Terpenoids | - |
| dc.subject.local | Type 2 diabetes | - |
| dc.subject.local | Type 2 Diabetes | - |
| dc.description.journalClass | Y | - |
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- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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