Evolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event

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dc.contributor.authorY J Kim-
dc.contributor.authorJae Won Huh-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorK Han-
dc.contributor.authorH M Kim-
dc.contributor.authorH S Kim-
dc.date.accessioned2017-04-19T09:28:25Z-
dc.date.available2017-04-19T09:28:25Z-
dc.date.issued2011-
dc.identifier.issn1341-7568-
dc.identifier.uri10.1266/ggs.86.277ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10541-
dc.description.abstractDYX1C1 is a candidate gene for developmental dyslexia and has three alternative pre-mRNA spliced forms in the human genome. One of the transcripts contains an HERV-H LTR that could affect the expression level of DYX1C1. We speculate that the HERV-H LTR integrated into the DYX1C1 locus in the catarrhine lineage after its divergence from the platyrrhine lineage. Reverse transcription-PCR of the HERV-H LTR-related transcript produced four alternative forms from several human tissues. All of alternative forms were also identified in various rhesus macaque tissues. Through sequencing analysis of various primate DNA samples, we found that a part of the HERV-H LTR sequence was duplicated within the DYX1C1 exon 9 only in catarrhines. However, the duplication event did not cause frameshift mutation of the DYX1C1 transcript. Taken together, this HERV-H LTR insertion into DYX1C1 has contributed to transcript diversification of DYX1C1 during primate evolution.-
dc.publisherGenetics Soc Japan-
dc.titleEvolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event-
dc.title.alternativeEvolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event-
dc.typeArticle-
dc.citation.titleGenes & Genetic Systems-
dc.citation.number4-
dc.citation.endPage284-
dc.citation.startPage277-
dc.citation.volume86-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.alternativeName김윤지-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName한규동-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName김희수-
dc.identifier.bibliographicCitationGenes & Genetic Systems, vol. 86, no. 4, pp. 277-284-
dc.identifier.doi10.1266/ggs.86.277-
dc.subject.keywordAlternative splicing-
dc.subject.keywordDuplication-
dc.subject.keywordDYX1C1 gene-
dc.subject.keywordExonization-
dc.subject.keywordHERV-H-
dc.subject.localAlternative splicing-
dc.subject.localalternative splicing-
dc.subject.localDuplication-
dc.subject.localDYX1C1 gene-
dc.subject.localExonization-
dc.subject.localHERV-H-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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