DC Field | Value | Language |
---|---|---|
dc.contributor.author | L Cui | - |
dc.contributor.author | Mun-Ock Kim | - |
dc.contributor.author | Jihee Seo | - |
dc.contributor.author | I S Kim | - |
dc.contributor.author | N Y Kim | - |
dc.contributor.author | S H Lee | - |
dc.contributor.author | JeongJun Park | - |
dc.contributor.author | J Kim | - |
dc.contributor.author | Hyun Sun Lee | - |
dc.date.accessioned | 2017-04-19T09:28:41Z | - |
dc.date.available | 2017-04-19T09:28:41Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | 10.1016/j.foodchem.2011.11.138 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10558 | - |
dc.description.abstract | Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) has been proposed as one of the drug targets for treating obesity and type 2 diabetes. Bioassay-guided fractionation of the MeOH-soluble extract of Rosmarinus officinalis yielded two new diacylglycerol acyltransferase (DGAT) inhibitory-abietane diterpenoids, 7β-hydroxy-20-deoxo-rosmaquinone (1) and 7β-methoxy-20-deoxo-rosmanol (2), along with six known components, carnosol (3), 7α-methoxyrosmanol (4), 7β-methoxyrosmanol (5), 12-methoxy-canosic acid (6), rosmanol (7), and rosmadial (8). Compounds 1-8 inhibited DGAT1 activity, with the IC 50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. In particular, carnosol (3), which is one of the major compounds of MeOH-soluble extract of R. officinalisexhibits inhibition of de novo intracellular triacylglycerol synthesis in human hepatocyte HepG2 cells. | - |
dc.publisher | Elsevier | - |
dc.title | Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity | - |
dc.title.alternative | Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity | - |
dc.type | Article | - |
dc.citation.title | Food Chemistry | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 1780 | - |
dc.citation.startPage | 1775 | - |
dc.citation.volume | 132 | - |
dc.contributor.affiliatedAuthor | Mun-Ock Kim | - |
dc.contributor.affiliatedAuthor | Jihee Seo | - |
dc.contributor.affiliatedAuthor | JeongJun Park | - |
dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
dc.contributor.alternativeName | Cui | - |
dc.contributor.alternativeName | 김문옥 | - |
dc.contributor.alternativeName | 서지희 | - |
dc.contributor.alternativeName | 김일순 | - |
dc.contributor.alternativeName | 김남예 | - |
dc.contributor.alternativeName | 이선화 | - |
dc.contributor.alternativeName | 박정준 | - |
dc.contributor.alternativeName | 김정우 | - |
dc.contributor.alternativeName | 이현선 | - |
dc.identifier.bibliographicCitation | Food Chemistry, vol. 132, no. 4, pp. 1775-1780 | - |
dc.identifier.doi | 10.1016/j.foodchem.2011.11.138 | - |
dc.subject.keyword | Abietane diterpenoid | - |
dc.subject.keyword | Carnosol | - |
dc.subject.keyword | Diacylglycerol acyltransferase | - |
dc.subject.keyword | Rosmarinus officinalis | - |
dc.subject.keyword | Triacylglycerol synthesis | - |
dc.subject.local | Abietane diterpenoids | - |
dc.subject.local | Abietane diterpenoid | - |
dc.subject.local | Carnosol | - |
dc.subject.local | diacylglycerol acyltransferase | - |
dc.subject.local | diacylglycerol acyltansferase (DGAT) | - |
dc.subject.local | Diacylglycerol acyltransferase | - |
dc.subject.local | Diacylglycerol acyltransferase (DGAT) | - |
dc.subject.local | Rosmarinus officinalis | - |
dc.subject.local | Rosmarinus officinalis (Anna Rosemary) | - |
dc.subject.local | Triacylglycerol synthesis | - |
dc.description.journalClass | Y | - |
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