Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity

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dc.contributor.authorL Cui-
dc.contributor.authorMun-Ock Kim-
dc.contributor.authorJihee Seo-
dc.contributor.authorI S Kim-
dc.contributor.authorN Y Kim-
dc.contributor.authorS H Lee-
dc.contributor.authorJeongJun Park-
dc.contributor.authorJ Kim-
dc.contributor.authorHyun Sun Lee-
dc.date.accessioned2017-04-19T09:28:41Z-
dc.date.available2017-04-19T09:28:41Z-
dc.date.issued2012-
dc.identifier.issn0308-8146-
dc.identifier.uri10.1016/j.foodchem.2011.11.138ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10558-
dc.description.abstractInhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) has been proposed as one of the drug targets for treating obesity and type 2 diabetes. Bioassay-guided fractionation of the MeOH-soluble extract of Rosmarinus officinalis yielded two new diacylglycerol acyltransferase (DGAT) inhibitory-abietane diterpenoids, 7β-hydroxy-20-deoxo-rosmaquinone (1) and 7β-methoxy-20-deoxo-rosmanol (2), along with six known components, carnosol (3), 7α-methoxyrosmanol (4), 7β-methoxyrosmanol (5), 12-methoxy-canosic acid (6), rosmanol (7), and rosmadial (8). Compounds 1-8 inhibited DGAT1 activity, with the IC 50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. In particular, carnosol (3), which is one of the major compounds of MeOH-soluble extract of R. officinalisexhibits inhibition of de novo intracellular triacylglycerol synthesis in human hepatocyte HepG2 cells.-
dc.publisherElsevier-
dc.titleAbietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity-
dc.title.alternativeAbietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity-
dc.typeArticle-
dc.citation.titleFood Chemistry-
dc.citation.number4-
dc.citation.endPage1780-
dc.citation.startPage1775-
dc.citation.volume132-
dc.contributor.affiliatedAuthorMun-Ock Kim-
dc.contributor.affiliatedAuthorJihee Seo-
dc.contributor.affiliatedAuthorJeongJun Park-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.alternativeNameCui-
dc.contributor.alternativeName김문옥-
dc.contributor.alternativeName서지희-
dc.contributor.alternativeName김일순-
dc.contributor.alternativeName김남예-
dc.contributor.alternativeName이선화-
dc.contributor.alternativeName박정준-
dc.contributor.alternativeName김정우-
dc.contributor.alternativeName이현선-
dc.identifier.bibliographicCitationFood Chemistry, vol. 132, no. 4, pp. 1775-1780-
dc.identifier.doi10.1016/j.foodchem.2011.11.138-
dc.subject.keywordAbietane diterpenoid-
dc.subject.keywordCarnosol-
dc.subject.keywordDiacylglycerol acyltransferase-
dc.subject.keywordRosmarinus officinalis-
dc.subject.keywordTriacylglycerol synthesis-
dc.subject.localAbietane diterpenoids-
dc.subject.localAbietane diterpenoid-
dc.subject.localCarnosol-
dc.subject.localdiacylglycerol acyltransferase-
dc.subject.localdiacylglycerol acyltansferase (DGAT)-
dc.subject.localDiacylglycerol acyltransferase-
dc.subject.localDiacylglycerol acyltransferase (DGAT)-
dc.subject.localRosmarinus officinalis-
dc.subject.localRosmarinus officinalis (Anna Rosemary)-
dc.subject.localTriacylglycerol synthesis-
dc.description.journalClassY-
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Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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