DC Field | Value | Language |
---|---|---|
dc.contributor.author | K D Yoo | - |
dc.contributor.author | E S Park | - |
dc.contributor.author | Y Lim | - |
dc.contributor.author | S I Kang | - |
dc.contributor.author | S H Yoo | - |
dc.contributor.author | H H Won | - |
dc.contributor.author | H P Lee | - |
dc.contributor.author | Y H Kim | - |
dc.contributor.author | Ick-Dong Yoo | - |
dc.contributor.author | H S Yoo | - |
dc.contributor.author | J T Hong | - |
dc.contributor.author | Y P Yun | - |
dc.date.accessioned | 2017-04-19T09:28:43Z | - |
dc.date.available | 2017-04-19T09:28:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1537-1891 | - |
dc.identifier.uri | 10.1016/j.vph.2011.11.004 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10560 | - |
dc.description.abstract | The increased proliferation of vascular smooth muscle cells (VSMCs) in the arterial wall is a critical pathogenic factor for vascular diseases such as atherosclerosis and restenosis after angioplasty. Clitocybin B was reported to have either a potent free radical scavenging effect or effects that were isolated from the culture broth of mushroom Clitocybe aurantiaca. The present study was designed to investigate the effects of clitocybin B on VSMC proliferation and its possible molecular mechanism. Clitocybin B significantly inhibited the proliferation and the DNA synthesis of PDGF-BB-stimulated VSMCs in a concentration-dependent manner. In agreement with these findings, clitocybin B suppressed the PDGF-BB-induced progression through G0/G1 to S phase of cell cycle. Clitocybin B also down-regulated the expressions of cell cycle-related proteins, including cyclin-dependent kinase (CDK)2, cyclin E, CDK4, cyclin D1, and proliferative cell nuclear antigen in PDGF-BB-stimulated VSMCs. Clitocybin B significantly inhibited the phosphorylation of Akt, extracellular signal-regulated kinase 1/2, and phospholipase C-γ1, in the PDGF-BB signaling pathway. Clitocybin B suppressed the PDGF-Rβ activation in PDGF-BB signaling cascade. These results suggested that the inhibitory effect of clitocybin B on the proliferation of VSMCs may be associated with suppressing PDGF-Rβ phosphorylation. Thus, clitocybin B may be an effective antiproliferative agent for the prevention of atherosclerosis and restenosis. | - |
dc.publisher | Elsevier | - |
dc.title | Clitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation | - |
dc.title.alternative | Clitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation | - |
dc.type | Article | - |
dc.citation.title | Vascular Pharmacology | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 97 | - |
dc.citation.startPage | 91 | - |
dc.citation.volume | 56 | - |
dc.contributor.affiliatedAuthor | Ick-Dong Yoo | - |
dc.contributor.alternativeName | 유규동 | - |
dc.contributor.alternativeName | 박은석 | - |
dc.contributor.alternativeName | 임용 | - |
dc.contributor.alternativeName | 강신일 | - |
dc.contributor.alternativeName | 유수향 | - |
dc.contributor.alternativeName | 원하희 | - |
dc.contributor.alternativeName | 이희봄 | - |
dc.contributor.alternativeName | 김영희 | - |
dc.contributor.alternativeName | 유익동 | - |
dc.contributor.alternativeName | 유환수 | - |
dc.contributor.alternativeName | 홍진태 | - |
dc.contributor.alternativeName | 윤여표 | - |
dc.identifier.bibliographicCitation | Vascular Pharmacology, vol. 56, no. 1, pp. 91-97 | - |
dc.identifier.doi | 10.1016/j.vph.2011.11.004 | - |
dc.subject.keyword | Clitocybin B → Clitocybin | - |
dc.subject.keyword | PDGF-R → atherosclerosis | - |
dc.subject.keyword | Proliferation | - |
dc.subject.keyword | Vascular smooth muscle cell | - |
dc.subject.local | Clitocybin B → Clitocybin | - |
dc.subject.local | PDGF-R → atherosclerosis | - |
dc.subject.local | proliferation | - |
dc.subject.local | Proliferation | - |
dc.subject.local | Vascular smooth muscle cell | - |
dc.subject.local | vascular smooth muscle cell | - |
dc.description.journalClass | Y | - |
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