Clitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation

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dc.contributor.authorK D Yoo-
dc.contributor.authorE S Park-
dc.contributor.authorY Lim-
dc.contributor.authorS I Kang-
dc.contributor.authorS H Yoo-
dc.contributor.authorH H Won-
dc.contributor.authorH P Lee-
dc.contributor.authorY H Kim-
dc.contributor.authorIck-Dong Yoo-
dc.contributor.authorH S Yoo-
dc.contributor.authorJ T Hong-
dc.contributor.authorY P Yun-
dc.date.accessioned2017-04-19T09:28:43Z-
dc.date.available2017-04-19T09:28:43Z-
dc.date.issued2012-
dc.identifier.issn1537-1891-
dc.identifier.uri10.1016/j.vph.2011.11.004ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10560-
dc.description.abstractThe increased proliferation of vascular smooth muscle cells (VSMCs) in the arterial wall is a critical pathogenic factor for vascular diseases such as atherosclerosis and restenosis after angioplasty. Clitocybin B was reported to have either a potent free radical scavenging effect or effects that were isolated from the culture broth of mushroom Clitocybe aurantiaca. The present study was designed to investigate the effects of clitocybin B on VSMC proliferation and its possible molecular mechanism. Clitocybin B significantly inhibited the proliferation and the DNA synthesis of PDGF-BB-stimulated VSMCs in a concentration-dependent manner. In agreement with these findings, clitocybin B suppressed the PDGF-BB-induced progression through G0/G1 to S phase of cell cycle. Clitocybin B also down-regulated the expressions of cell cycle-related proteins, including cyclin-dependent kinase (CDK)2, cyclin E, CDK4, cyclin D1, and proliferative cell nuclear antigen in PDGF-BB-stimulated VSMCs. Clitocybin B significantly inhibited the phosphorylation of Akt, extracellular signal-regulated kinase 1/2, and phospholipase C-γ1, in the PDGF-BB signaling pathway. Clitocybin B suppressed the PDGF-Rβ activation in PDGF-BB signaling cascade. These results suggested that the inhibitory effect of clitocybin B on the proliferation of VSMCs may be associated with suppressing PDGF-Rβ phosphorylation. Thus, clitocybin B may be an effective antiproliferative agent for the prevention of atherosclerosis and restenosis.-
dc.publisherElsevier-
dc.titleClitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation-
dc.title.alternativeClitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation-
dc.typeArticle-
dc.citation.titleVascular Pharmacology-
dc.citation.number1-
dc.citation.endPage97-
dc.citation.startPage91-
dc.citation.volume56-
dc.contributor.affiliatedAuthorIck-Dong Yoo-
dc.contributor.alternativeName유규동-
dc.contributor.alternativeName박은석-
dc.contributor.alternativeName임용-
dc.contributor.alternativeName강신일-
dc.contributor.alternativeName유수향-
dc.contributor.alternativeName원하희-
dc.contributor.alternativeName이희봄-
dc.contributor.alternativeName김영희-
dc.contributor.alternativeName유익동-
dc.contributor.alternativeName유환수-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName윤여표-
dc.identifier.bibliographicCitationVascular Pharmacology, vol. 56, no. 1, pp. 91-97-
dc.identifier.doi10.1016/j.vph.2011.11.004-
dc.subject.keywordClitocybin B → Clitocybin-
dc.subject.keywordPDGF-R → atherosclerosis-
dc.subject.keywordProliferation-
dc.subject.keywordVascular smooth muscle cell-
dc.subject.localClitocybin B → Clitocybin-
dc.subject.localPDGF-R → atherosclerosis-
dc.subject.localproliferation-
dc.subject.localProliferation-
dc.subject.localVascular smooth muscle cell-
dc.subject.localvascular smooth muscle cell-
dc.description.journalClassY-
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