DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyun Mee Oh | - |
dc.contributor.author | Seung Woong Lee | - |
dc.contributor.author | M H Park | - |
dc.contributor.author | Mi-Hwa Kim | - |
dc.contributor.author | Young Bae Ryu | - |
dc.contributor.author | M S Kim | - |
dc.contributor.author | H H Kim | - |
dc.contributor.author | K H Park | - |
dc.contributor.author | Woo Song Lee | - |
dc.contributor.author | Su-Jin Park | - |
dc.contributor.author | Mun Chual Rho | - |
dc.date.accessioned | 2017-04-19T09:28:48Z | - |
dc.date.available | 2017-04-19T09:28:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1347-8613 | - |
dc.identifier.uri | 10.1254/jphs.11077FP | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10584 | - |
dc.description.abstract | This study examined the effect of norkurarinol on the toll-like receptor 3 (TLR3)- mediated signaling pathways and rotavirus replication. Norkurarinol, a lavandulylated flavanone, was isolated from the roots of Sophora flavescens, which has been shown to have anti-inflammatory activity. Norkurarinol suppressed the NF-κB and AP-1 inducible secreted embryonic alkaline phosphatase (SEAP) activity induced by poly(I:C), TLR3 ligand, in THP1-Blue-CD14 cells with IC 50 values of 20.9 μM. Norkurarinol also significantly suppressed the mRNA expression of proinflammatory and adhesive molecules induced by poly(I:C) and rotavirus infection. Pretreatment of norkurarinol blocked the NF-κB and AP-1 signaling pathway and the phosphorylation of MAPKs induced by poly(I:C). On the other hand, norkurarinol increased the level of IRF3 phosphorylation and IFNβ expression in a dose-dependent manner. Moreover, norkurarinol inhibited the rotavirus-induced cytopathic effects. These results suggest that norkurarinol can modulate the TLR3-mediated inflammatory responses and rotavirus replication. | - |
dc.publisher | Japanese Pharmacological Soc | - |
dc.title | Norkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication | - |
dc.title.alternative | Norkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication | - |
dc.type | Article | - |
dc.citation.title | Journal of Pharmacological Sciences | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 170 | - |
dc.citation.startPage | 161 | - |
dc.citation.volume | 118 | - |
dc.contributor.affiliatedAuthor | Hyun Mee Oh | - |
dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
dc.contributor.affiliatedAuthor | Mi-Hwa Kim | - |
dc.contributor.affiliatedAuthor | Young Bae Ryu | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.affiliatedAuthor | Su-Jin Park | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.alternativeName | 오현미 | - |
dc.contributor.alternativeName | 이승웅 | - |
dc.contributor.alternativeName | 박미혜 | - |
dc.contributor.alternativeName | 김미화 | - |
dc.contributor.alternativeName | 류영배 | - |
dc.contributor.alternativeName | 김묘선 | - |
dc.contributor.alternativeName | 김하현 | - |
dc.contributor.alternativeName | 박기훈 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.contributor.alternativeName | 박수진 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.identifier.bibliographicCitation | Journal of Pharmacological Sciences, vol. 118, no. 2, pp. 161-170 | - |
dc.identifier.doi | 10.1254/jphs.11077FP | - |
dc.subject.keyword | dsRNA | - |
dc.subject.keyword | Inflammatory response | - |
dc.subject.keyword | Norkurarinol | - |
dc.subject.keyword | Rotavirus | - |
dc.subject.keyword | Toll-like receptor 3 (TLR3) | - |
dc.subject.local | dsRNA | - |
dc.subject.local | Inflammatory Response | - |
dc.subject.local | inflammatory response | - |
dc.subject.local | Inflammatory response | - |
dc.subject.local | Norkurarinol | - |
dc.subject.local | Rotavirus | - |
dc.subject.local | Toll-like receptor 3 (TLR3) | - |
dc.subject.local | toll-like receptor 3 | - |
dc.description.journalClass | Y | - |
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