Norkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication

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dc.contributor.authorHyun Mee Oh-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorM H Park-
dc.contributor.authorMi-Hwa Kim-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorM S Kim-
dc.contributor.authorH H Kim-
dc.contributor.authorK H Park-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorSu-Jin Park-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2017-04-19T09:28:48Z-
dc.date.available2017-04-19T09:28:48Z-
dc.date.issued2012-
dc.identifier.issn1347-8613-
dc.identifier.uri10.1254/jphs.11077FPko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10584-
dc.description.abstractThis study examined the effect of norkurarinol on the toll-like receptor 3 (TLR3)- mediated signaling pathways and rotavirus replication. Norkurarinol, a lavandulylated flavanone, was isolated from the roots of Sophora flavescens, which has been shown to have anti-inflammatory activity. Norkurarinol suppressed the NF-κB and AP-1 inducible secreted embryonic alkaline phosphatase (SEAP) activity induced by poly(I:C), TLR3 ligand, in THP1-Blue-CD14 cells with IC 50 values of 20.9 μM. Norkurarinol also significantly suppressed the mRNA expression of proinflammatory and adhesive molecules induced by poly(I:C) and rotavirus infection. Pretreatment of norkurarinol blocked the NF-κB and AP-1 signaling pathway and the phosphorylation of MAPKs induced by poly(I:C). On the other hand, norkurarinol increased the level of IRF3 phosphorylation and IFNβ expression in a dose-dependent manner. Moreover, norkurarinol inhibited the rotavirus-induced cytopathic effects. These results suggest that norkurarinol can modulate the TLR3-mediated inflammatory responses and rotavirus replication.-
dc.publisherJapanese Pharmacological Soc-
dc.titleNorkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication-
dc.title.alternativeNorkurarinol inhibits toll-like receptor 3 (TLR3)-mediated pro-inflammatory signaling pathway and rotavirus replication-
dc.typeArticle-
dc.citation.titleJournal of Pharmacological Sciences-
dc.citation.number2-
dc.citation.endPage170-
dc.citation.startPage161-
dc.citation.volume118-
dc.contributor.affiliatedAuthorHyun Mee Oh-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorMi-Hwa Kim-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorSu-Jin Park-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName오현미-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName박미혜-
dc.contributor.alternativeName김미화-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName김묘선-
dc.contributor.alternativeName김하현-
dc.contributor.alternativeName박기훈-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName박수진-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationJournal of Pharmacological Sciences, vol. 118, no. 2, pp. 161-170-
dc.identifier.doi10.1254/jphs.11077FP-
dc.subject.keyworddsRNA-
dc.subject.keywordInflammatory response-
dc.subject.keywordNorkurarinol-
dc.subject.keywordRotavirus-
dc.subject.keywordToll-like receptor 3 (TLR3)-
dc.subject.localdsRNA-
dc.subject.localInflammatory Response-
dc.subject.localinflammatory response-
dc.subject.localInflammatory response-
dc.subject.localNorkurarinol-
dc.subject.localRotavirus-
dc.subject.localToll-like receptor 3 (TLR3)-
dc.subject.localtoll-like receptor 3-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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