Dysregulation of overexpressed IL-32alpha in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-kappaB and Bcl-2

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dc.contributor.authorYun Hee Kang-
dc.contributor.authorM Y Park-
dc.contributor.authorD Y Yoon-
dc.contributor.authorS R Han-
dc.contributor.authorC I Lee-
dc.contributor.authorN Y Ji-
dc.contributor.authorP K Myung-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorJae Wha Kim-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorYe Jin Jang-
dc.contributor.authorD K Ahn-
dc.contributor.authorJ W Kim-
dc.contributor.authorEun Young Song-
dc.date.accessioned2017-04-19T09:28:51Z-
dc.date.available2017-04-19T09:28:51Z-
dc.date.issued2012-
dc.identifier.issn0304-3835-
dc.identifier.uri10.1016/j.canlet.2011.12.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10602-
dc.description.abstractIL-32 is a newly discovered cytokine. Recently, various reports suggest that it plays a role as a proinflammatory mediator and may be involved in several cancer carcinogenesis. However, IL-32 expression in hepatocellular carcinoma (HCC) remains unclear. In this study, we investigated the expression and role of IL-32α in hepatocellular carcinoma, because IL-32 was identified as an upregulated gene in hepatocellular carcinoma tissues compared to nontumorous regions using DNA microarray. IL-32α was overexpressed in tissue and serum from patients with HCC and localized in the cytoplasm and nucleus of hepatocellular carcinoma tumor cells. Moreover, secreted IL-32α concentration in the serum of patients with hepatocellular carcinoma was elevated as compared with those in the normal serum using a developed sandwich ELISA. Furthermore, IL-32α suppression in hepatocellular carcinoma decreased expression of phospho-p38 MAPK, NF-κB, and antiapoptotic protein Bcl-2 and induced expression of proapoptotic proteins as well as p53 and PUMA resulting in the suppression of cell growth and induction of intrinsic apoptosis. Based on our results, we suggest that IL-32α is involved in the progression of hepatocellular carcinoma and may be a useful biomarker for diagnosis and therapeutic target of hepatocellular carcinoma.-
dc.publisherElsevier-
dc.titleDysregulation of overexpressed IL-32alpha in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-kappaB and Bcl-2-
dc.title.alternativeDysregulation of overexpressed IL-32alpha in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-kappaB and Bcl-2-
dc.typeArticle-
dc.citation.titleCancer Letters-
dc.citation.number2-
dc.citation.endPage233-
dc.citation.startPage226-
dc.citation.volume318-
dc.contributor.affiliatedAuthorYun Hee Kang-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorYe Jin Jang-
dc.contributor.affiliatedAuthorEun Young Song-
dc.contributor.alternativeName강윤희-
dc.contributor.alternativeName박미영-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName한승로-
dc.contributor.alternativeName이정일-
dc.contributor.alternativeName지나영-
dc.contributor.alternativeName명평근-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName김재화-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName장예진-
dc.contributor.alternativeName안동국-
dc.contributor.alternativeName김종완-
dc.contributor.alternativeName송은영-
dc.identifier.bibliographicCitationCancer Letters, vol. 318, no. 2, pp. 226-233-
dc.identifier.doi10.1016/j.canlet.2011.12.023-
dc.subject.keywordApoptosis-
dc.subject.keywordCell growth-
dc.subject.keywordDiagnostic marker-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordIL-32α-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localCell growth-
dc.subject.localcell growth-
dc.subject.localCell Growth-
dc.subject.localDiagnostic marker-
dc.subject.localdiagnotic marker-
dc.subject.localdiagnostic marker-
dc.subject.localHepatocellular carcinomas-
dc.subject.localHepatocellular carcinoma (HCC)-
dc.subject.localHepatocellular carcinoma-
dc.subject.localhepatocellular carcinoma (HCC)-
dc.subject.localhepatocellular carcinoma-
dc.subject.localIL-32α-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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