High-contrast reversible fluorescence photoswitching of dye-crosslinked dendritic nanoclusters in living vertebrates

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Title
High-contrast reversible fluorescence photoswitching of dye-crosslinked dendritic nanoclusters in living vertebrates
Author(s)
Yoonkyung Kim; Hye-youn Jung; Yun Hui Choe; Chaewoon Lee; Sung-Kyun Ko; S Koun; Y Choi; Bong Hyun Chung; Byoung Chul Park; T L Huh; I Shin; E Kim
Bibliographic Citation
Angewandte Chemie-International Edition, vol. 51, no. 12, pp. 2878-2882
Publication Year
2012
Abstract
Dendrimers crosslinked with a photochromic diarylethene (blue in picture) were labeled with the fluorescent dye Cy3 (red) for reversible fluorescence photoswitching. If the obtained nanoclusters are irradiated with UV light, the Cy3 fluorescence is quenched by the diarylethene in its ring-closed form, whereas upon irradiation with visible light, the nanoclusters show fluorescence. High-contrast fluorescence imaging was achieved inside a living zebrafish.
Keyword
dendrimersfluorescenceFRETphotoswitchzebrafish
ISSN
1433-7851
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/anie.201107086
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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