Clitocybin A, a novel isoindolinone, from the mushroom Clitocybe aurantiaca, inhibits cell proliferation through G1 phase arrest by regulating the PI3K/Akt cascade in vascular smooth muscle cells

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dc.contributor.authorK D Yoo-
dc.contributor.authorE S Park-
dc.contributor.authorY Lim-
dc.contributor.authorS I Kang-
dc.contributor.authorS H Yoo-
dc.contributor.authorH H Won-
dc.contributor.authorY H Kim-
dc.contributor.authorIck-Dong Yoo-
dc.contributor.authorH S Yoo-
dc.contributor.authorJ T Hong-
dc.contributor.authorY P Yun-
dc.date.accessioned2017-04-19T09:28:55Z-
dc.date.available2017-04-19T09:28:55Z-
dc.date.issued2012-
dc.identifier.issn1347-8613-
dc.identifier.uri10.1254/jphs.11159FPko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10620-
dc.description.abstractAbnormal proliferation of vascular smooth muscle cells (VSMCs) plays an essential role in the pathogenesis of vascular diseases, such as atherosclerosis, hypertension, and restenosis. Clitocybin A, a novel isoindolinone, isolated from the culture broth of mushroom Clitocybe aurantiaca has been reported to possess free radical scavenging activity. However, the antiproliferative effects of clitocybin A on VSMCs are unknown. In the present study, we investigated the effect of clitocybin A on platelet-derived growth factor (PDGF)-BB-induced proliferation of VSMCs and examined the molecular basis of the underlying mechanism. Clitocybin A inhibited DNA synthesis and cell proliferation. In accordance with these findings, clitocybin A blocked the PDGF-BB-inducible progression through G0/G1 to S phase of the cell cycle in synchronized cells and decreased the expression of cyclin-dependent kinase (CDK) 2, CDK4, cyclin D1, cyclin E, and proliferative cell nuclear antigen. In addition, clitocybin A inhibited the PDGF-BB-induced phosphorylation of phosphatidylinositol 3 kinase (PI3K) / Akt kinase. However, clitocybin A did not change the expression levels of extracellular signal-related kinase (ERK) 1/2, phospholipase C-γ1, and PDGF-Rβ phosphorylation. These results indicate that clitocybin A may inhibit VSMCs proliferation through G1 phase arrest by regulating the PI3K/Akt pathway.-
dc.publisherJapanese Pharmacological Soc-
dc.titleClitocybin A, a novel isoindolinone, from the mushroom Clitocybe aurantiaca, inhibits cell proliferation through G1 phase arrest by regulating the PI3K/Akt cascade in vascular smooth muscle cells-
dc.title.alternativeClitocybin A, a novel isoindolinone, from the mushroom Clitocybe aurantiaca, inhibits cell proliferation through G1 phase arrest by regulating the PI3K/Akt cascade in vascular smooth muscle cells-
dc.typeArticle-
dc.citation.titleJournal of Pharmacological Sciences-
dc.citation.number2-
dc.citation.endPage177-
dc.citation.startPage171-
dc.citation.volume118-
dc.contributor.affiliatedAuthorIck-Dong Yoo-
dc.contributor.alternativeName유규동-
dc.contributor.alternativeName박은석-
dc.contributor.alternativeName임용-
dc.contributor.alternativeName강신일-
dc.contributor.alternativeName유수향-
dc.contributor.alternativeName원하희-
dc.contributor.alternativeName김영희-
dc.contributor.alternativeName유익동-
dc.contributor.alternativeName유환수-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName윤여표-
dc.identifier.bibliographicCitationJournal of Pharmacological Sciences, vol. 118, no. 2, pp. 171-177-
dc.identifier.doi10.1254/jphs.11159FP-
dc.subject.keywordClitocybin A-
dc.subject.keywordPI3K/Akt pathway-
dc.subject.keywordPlatelet-derived growth factor (PDGF)-BB-
dc.subject.keywordVascular smooth muscle cell-
dc.subject.localClitocybin A-
dc.subject.localclitocybin A-
dc.subject.localPI3K/Akt pathway-
dc.subject.localPI3K-AKT pathway-
dc.subject.localPlatelet-derived growth factor (PDGF)-BB-
dc.subject.localVascular smooth muscle cell-
dc.subject.localvascular smooth muscle cell-
dc.description.journalClassY-
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