Screening of the inhibitory activity of Korea local plant extracts against indoleamine 2,3-dioxygenase (IDO) = 한국 자생식물 추출물의 Indoleamine 2,3-dioxygenase (IDO) 저해활성

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Title
Screening of the inhibitory activity of Korea local plant extracts against indoleamine 2,3-dioxygenase (IDO) = 한국 자생식물 추출물의 Indoleamine 2,3-dioxygenase (IDO) 저해활성
Author(s)
Jun-Pil JangJae-Hyuk Jang; Eun Young Bae; Sook-Jung Jeong; Hae-Min Kim; M R Kim; Nak Kyun SoungBo Yeon KimJong Seog Ahn
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 42, no. 4, pp. 379-385
Publication Year
2011
Abstract
Indoleamine 2,3-dioxygenase (IDO) is predicted to be therapeutic target for treatment of cancer and immune disease. Thus, we examined methanol extracts prepared from 156 Korean local plants for their inhibitory effects on IDO in vitro. Among them sixteen extracts showed more than 50% inhibition of IDO activity at the concentration of 30 μg/ml . Especially, the extracts of Platycarya strobilacea, Quercus acutissima, Acer ginnala and Alnus japonica were most potent because their IC50 value were 6.5, 8.1, 3.9 and 4.2 μg/ml , respectively.
Keyword
Indoleamine 23-dioxygenasecancertryptophanplant extracts.
ISSN
0253-3073
Publisher
South Korea
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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