Tigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii

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dc.contributor.authorY H Pei-
dc.contributor.authorJae Wha Kim-
dc.contributor.authorHo Bum Kang-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorC S Kim-
dc.contributor.authorHyuk Hwan Song-
dc.contributor.authorY W Chin-
dc.contributor.authorSei Ryang Oh-
dc.date.accessioned2017-04-19T09:29:01Z-
dc.date.available2017-04-19T09:29:01Z-
dc.date.issued2012-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2012.01.057ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10633-
dc.description.abstractBioactivity-guided fractionation on the leaves of Aleurites fordii led to the isolation of a new tigliane diterpene ester, 12-O-hexadecanoyl-7-oxo-5-ene- 16-hydroxyphorbol-13-acetate (1) along with four known compounds, 12-O-hexadecanoyl-7-oxo-5-ene-phorbol-13-acetate (2), 12-O-hexadecanoyl-phorbol- 13-acetate (3), 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate (4), and 12-O-hexadecanoyl-4-deoxy-4α-16-hydroxyphorbol-13-acetate (5). The structures of these compounds were determined by interpretation of NMR (1D and 2D) spectroscopic data and MS data. All the isolates were evaluated for their effects on the induction of IFN-γ in NK92 cells. Compounds 3 and 4 exhibited the most potent responses in IFN-γ induction, comparable to the positive control, phorbol 12-myristate 13-acetate (PMA).-
dc.publisherElsevier-
dc.titleTigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii-
dc.title.alternativeTigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number6-
dc.citation.endPage2320-
dc.citation.startPage2318-
dc.citation.volume22-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.affiliatedAuthorHo Bum Kang-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.affiliatedAuthorHyuk Hwan Song-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.alternativeNamePei-
dc.contributor.alternativeName김재화-
dc.contributor.alternativeName강호범-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName김찬수-
dc.contributor.alternativeName송혁환-
dc.contributor.alternativeName진영원-
dc.contributor.alternativeName오세량-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 22, no. 6, pp. 2318-2320-
dc.identifier.doi10.1016/j.bmcl.2012.01.057-
dc.subject.keywordAleurites fordii-
dc.subject.keywordEuphorbiaceae-
dc.subject.keywordIFN-γ production-
dc.subject.keywordPhorbol-
dc.subject.keywordTigliane diterpene-
dc.subject.localAleurites fordii-
dc.subject.localeuphorbiaceae-
dc.subject.localEuphorbiaceae-
dc.subject.localIFN-γ production-
dc.subject.localPhorbol-
dc.subject.localTigliane diterpene-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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