DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ok-Kyoung Kwon | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.contributor.author | Ji Won Park | - |
dc.contributor.author | Ha young Jang | - |
dc.contributor.author | Hyouk Joung | - |
dc.contributor.author | Hyeong Kyu Lee | - |
dc.contributor.author | Sei Ryang Oh | - |
dc.date.accessioned | 2017-04-19T09:29:29Z | - |
dc.date.available | 2017-04-19T09:29:29Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0360-3997 | - |
dc.identifier.uri | 10.1007/s10753-011-9343-3 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10657 | - |
dc.description.abstract | Elaeocarpus petiolatus is known to exert active oxygen scavenging, anti-aging, and whitening actions. However, the biological effects of E. petiolatus on inflammation and the underlying mechanisms are yet to be established. In the present study, we investigated the anti-inflammatory effects of the ethanol extract from E. petiolatus (EPE) bark in murine Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). EPE inhibited the production of PGE2, TNF-α, and IL-1β in a dose-dependent manner in Raw264.7 cells stimulated with LPS. The decrease in PGE2 production was correlated with reduced COX-2 expression. Furthermore, EPE suppressed the phosphorylation of extracellular signal-related kinases (ERK), c-Jun N-terminal kinase (JNK), and p38 as well as translocation of the NF-κB p65 subunit from the cytosol to nucleus. Our results suggest that EPE exerts anti-inflammatory activity through inhibition of inflammatory mediators, such as PGE2, TNF-α, and IL-1β, and downregulation of COX-2 via suppression of NF-κB translocation and phosphorylation of ERK, JNK, and p38 in LPS-stimulated Raw264.7 cells. | - |
dc.publisher | Springer | - |
dc.title | Ethanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells = 엘리오카퍼스 페티오라투스의 LPS-유도 염증억제 | - |
dc.title.alternative | Ethanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells | - |
dc.type | Article | - |
dc.citation.title | Inflammation | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 544 | - |
dc.citation.startPage | 535 | - |
dc.citation.volume | 35 | - |
dc.contributor.affiliatedAuthor | Ok-Kyoung Kwon | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.affiliatedAuthor | Ji Won Park | - |
dc.contributor.affiliatedAuthor | Ha young Jang | - |
dc.contributor.affiliatedAuthor | Hyouk Joung | - |
dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
dc.contributor.affiliatedAuthor | Sei Ryang Oh | - |
dc.contributor.alternativeName | 권옥경 | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.contributor.alternativeName | 박지원 | - |
dc.contributor.alternativeName | 장하영 | - |
dc.contributor.alternativeName | 정혁 | - |
dc.contributor.alternativeName | 이형규 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.identifier.bibliographicCitation | Inflammation, vol. 35, no. 2, pp. 535-544 | - |
dc.identifier.doi | 10.1007/s10753-011-9343-3 | - |
dc.subject.keyword | COX-2 | - |
dc.subject.keyword | Elaeocarpus petiolatus | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | MAPK | - |
dc.subject.keyword | NF-kappaB | - |
dc.subject.local | COX-2 | - |
dc.subject.local | Cox-2 | - |
dc.subject.local | Elaeocarpus petiolatus | - |
dc.subject.local | inflammation | - |
dc.subject.local | Inflammation | - |
dc.subject.local | MAPK | - |
dc.subject.local | MAPKs | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.description.journalClass | Y | - |
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