Ethanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells = 엘리오카퍼스 페티오라투스의 LPS-유도 염증억제

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dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorJi Won Park-
dc.contributor.authorHa young Jang-
dc.contributor.authorHyouk Joung-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorSei Ryang Oh-
dc.date.accessioned2017-04-19T09:29:29Z-
dc.date.available2017-04-19T09:29:29Z-
dc.date.issued2012-
dc.identifier.issn03603997-
dc.identifier.uri10.1007/s10753-011-9343-3ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10657-
dc.description.abstractElaeocarpus petiolatus is known to exert active oxygen scavenging, anti-aging, and whitening actions. However, the biological effects of E. petiolatus on inflammation and the underlying mechanisms are yet to be established. In the present study, we investigated the anti-inflammatory effects of the ethanol extract from E. petiolatus (EPE) bark in murine Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). EPE inhibited the production of PGE2, TNF-α, and IL-1β in a dose-dependent manner in Raw264.7 cells stimulated with LPS. The decrease in PGE2 production was correlated with reduced COX-2 expression. Furthermore, EPE suppressed the phosphorylation of extracellular signal-related kinases (ERK), c-Jun N-terminal kinase (JNK), and p38 as well as translocation of the NF-κB p65 subunit from the cytosol to nucleus. Our results suggest that EPE exerts anti-inflammatory activity through inhibition of inflammatory mediators, such as PGE2, TNF-α, and IL-1β, and downregulation of COX-2 via suppression of NF-κB translocation and phosphorylation of ERK, JNK, and p38 in LPS-stimulated Raw264.7 cells.-
dc.publisherSpringer-
dc.titleEthanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells = 엘리오카퍼스 페티오라투스의 LPS-유도 염증억제-
dc.title.alternativeEthanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells-
dc.typeArticle-
dc.citation.titleInflammation-
dc.citation.number2-
dc.citation.endPage544-
dc.citation.startPage535-
dc.citation.volume35-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName박지원-
dc.contributor.alternativeName장하영-
dc.contributor.alternativeName정혁-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName오세량-
dc.identifier.bibliographicCitationInflammation, vol. 35, no. 2, pp. 535-544-
dc.identifier.doi10.1007/s10753-011-9343-3-
dc.subject.keywordCOX-2-
dc.subject.keywordElaeocarpus petiolatus-
dc.subject.keywordinflammation-
dc.subject.keywordMAPK-
dc.subject.keywordNF-kappaB-
dc.subject.localCOX-2-
dc.subject.localElaeocarpus petiolatus-
dc.subject.localinflammation-
dc.subject.localInflammation-
dc.subject.localMAPK-
dc.subject.localNF-kappaB-
dc.subject.localNF-kB-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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