Convenient synthesis of an isoxazole compound, KRIBB3, as an anticancer agent

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Title
Convenient synthesis of an isoxazole compound, KRIBB3, as an anticancer agent
Author(s)
Hyeong Kyu Lee; Eun Ju Yun; Ji Hye Min; Kab Seog Yoon; Dong-Ho Choung; Sangku Lee
Bibliographic Citation
Synthetic Communications, vol. 42, no. 13, pp. 1890-1894
Publication Year
2012
Abstract
A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents at an aryl moiety for structure-activity relationships (SAR), as well as a large quantity of KRIBB3 for in vivo studies.
Keyword
Anticancerantimigratorycyclizationisoxazole
ISSN
0039-7911
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/00397911.2010.546551
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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