Convenient synthesis of an isoxazole compound, KRIBB3, as an anticancer agent
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- Title
- Convenient synthesis of an isoxazole compound, KRIBB3, as an anticancer agent
- Author(s)
- Hyeong Kyu Lee; Eun Ju Yun; Ji Hye Min; Kab Seog Yoon; Dong-Ho Choung; Sangku Lee
- Bibliographic Citation
- Synthetic Communications, vol. 42, no. 13, pp. 1890-1894
- Publication Year
- 2012
- Abstract
- A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents at an aryl moiety for structure-activity relationships (SAR), as well as a large quantity of KRIBB3 for in vivo studies.
- Keyword
- Anticancerantimigratorycyclizationisoxazole
- ISSN
- 0039-7911
- Publisher
- T&F (Taylor & Francis)
- DOI
- http://dx.doi.org/10.1080/00397911.2010.546551
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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