Induction of type I interferon by high-molecular poly-γ-glutamate protects B6.A2G-Mx1 mice against influenza A virus

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Title
Induction of type I interferon by high-molecular poly-γ-glutamate protects B6.A2G-Mx1 mice against influenza A virus
Author(s)
H J Moon; J S Lee; Y K Choi; J Y Park; M R Talactac; M Y E Chowdhury; Haryoung Poo; M H Sung; J H Lee; J U Jung; C J Kim
Bibliographic Citation
Antiviral Research, vol. 94, no. 1, pp. 98-102
Publication Year
2012
Abstract
In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-γ-glutamate (HM-γ-PGA) produced by Bacillus subtilis chungkookjang was evaluated for anti-influenza virus activity. HM-γ-PGA induced type I interferons (IFNs), which in turn stimulated expression of Myxovirus resistant 1 protein and IFN-related proteins in vitro. In the B6.A2G- Mx1 mouse model, which mimics the innate immune system of humans, treatment with HM-γ-PGA enhanced the antiviral state of mice and protected them against highly pathogenic influenza A virus. Naturally synthesized HM-γ-PGA has potent anti-influenza activity and may be a useful means for control of influenza virus.
Keyword
B6.A2G-Mx1 mouseHigh-molecular-weight poly-γ-glutamateInfluenza A virusInterferon type IMyxovirus resistance protein
ISSN
0166-3542
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.antiviral.2012.02.010
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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