Cited 17 time in
- Title
- Induction of type I interferon by high-molecular poly-γ-glutamate protects B6.A2G-Mx1 mice against influenza A virus
- Author(s)
- H J Moon; J S Lee; Y K Choi; J Y Park; M R Talactac; M Y E Chowdhury; Haryoung Poo; M H Sung; J H Lee; J U Jung; C J Kim
- Bibliographic Citation
- Antiviral Research, vol. 94, no. 1, pp. 98-102
- Publication Year
- 2012
- Abstract
- In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-γ-glutamate (HM-γ-PGA) produced by Bacillus subtilis chungkookjang was evaluated for anti-influenza virus activity. HM-γ-PGA induced type I interferons (IFNs), which in turn stimulated expression of Myxovirus resistant 1 protein and IFN-related proteins in vitro. In the B6.A2G- Mx1 mouse model, which mimics the innate immune system of humans, treatment with HM-γ-PGA enhanced the antiviral state of mice and protected them against highly pathogenic influenza A virus. Naturally synthesized HM-γ-PGA has potent anti-influenza activity and may be a useful means for control of influenza virus.
- Keyword
- B6.A2G-Mx1 mouseHigh-molecular-weight poly-γ-glutamateInfluenza A virusInterferon type IMyxovirus resistance protein
- ISSN
- 0166-3542
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.antiviral.2012.02.010
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
- Files in This Item:
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