DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21 Cip1

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dc.contributor.authorJ W Lee-
dc.contributor.authorH S Kim-
dc.contributor.authorS Kim-
dc.contributor.authorJ Hwang-
dc.contributor.authorY H Kim-
dc.contributor.authorG Y Lim-
dc.contributor.authorW J Sohn-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorJ Y Kim-
dc.contributor.authorT S Park-
dc.contributor.authorK M Park-
dc.contributor.authorZ Y Ryoo-
dc.contributor.authorS Lee-
dc.date.accessioned2017-04-19T09:29:30Z-
dc.date.available2017-04-19T09:29:30Z-
dc.date.issued2012-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2012.02.120ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10666-
dc.description.abstractThe cell-fate determination factor Dachshund, a component of the Retinal Determination Gene Network (RDGN), has a role in breast tumor proliferation through the repression of cyclin D1 and several key regulators of embryonic stem cell function, such as Nanog and Sox2. However, little is known about the role of DACH1 in a myeloid lineage as a cell cycle regulator. Here, we identified the differential expression levels of extensive cell cycle regulators controlled by DACH1 in myeloid progenitor cells. The forced expression of DACH1 induced p27. Kip1 and repressed p21. Cip1, which is a pivotal characteristic of the myeloid progenitor. Furthermore, DACH1 significantly increased the expression of cyclin D1, D3, F, and Cdk 1, 4, and 6 in myeloid progenitor cells. The knockdown of DACH1 blocked the cell cycle progression of HL-60 promyeloblastic cells through the decrease of cyclin D1, D3, F, and Cdk 1, 4, and 6 and increase in p21. Cip1, which in turn decreased the phosphorylation of the Rb protein. The expression of Sox2, Oct4, and Klf4 was significantly up-regulated by the forced expression of DACH1 in mouse myeloid progenitor cells.-
dc.publisherElsevier-
dc.titleDACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21 Cip1-
dc.title.alternativeDACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21 Cip1-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage95-
dc.citation.startPage91-
dc.citation.volume420-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.alternativeName이재웅-
dc.contributor.alternativeName김형수-
dc.contributor.alternativeName김성곤-
dc.contributor.alternativeName황준모-
dc.contributor.alternativeName김영훈-
dc.contributor.alternativeName임가영-
dc.contributor.alternativeName손원주-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName김재영-
dc.contributor.alternativeName박태성-
dc.contributor.alternativeName박권무-
dc.contributor.alternativeName유재영-
dc.contributor.alternativeName이상규-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 420, no. 1, pp. 91-95-
dc.identifier.doi10.1016/j.bbrc.2012.02.120-
dc.subject.keywordCCND-
dc.subject.keywordDACH1-
dc.subject.keywordMLL-AF9-
dc.subject.keywordMyeloid leukemia-
dc.subject.keywordP21 Cip1-
dc.subject.localCCND-
dc.subject.localDACH1-
dc.subject.localMLL-AF9-
dc.subject.localMyeloid leukemia-
dc.subject.localP21 Cip1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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