Aflaquinolones A-G: Secondary metabolites from marine and fungicolous isolates of aspergillus spp.

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Title
Aflaquinolones A-G: Secondary metabolites from marine and fungicolous isolates of aspergillus spp.
Author(s)
S A Neff; S U Lee; Y Asami; Jong Seog Ahn; H Oh; J Baltrusaitis; J B Gloer; D T Wicklow
Bibliographic Citation
Journal of Natural Products, vol. 75, no. 3, pp. 464-472
Publication Year
2012
Abstract
Seven new compounds (aflaquinolones A-G; 1-7) containing dihydroquinolin-2-one and terpenoid units have been isolated from two different fungal sources. Two of these metabolites (1 and 2) were obtained from a Hawaiian fungicolous isolate of Aspergillus sp. (section Flavipedes; MYC-2048 = NRRL 58570), while the others were obtained from a marine Aspergillus isolate (SF-5044) collected in Korea. The structures of these compounds were determined mainly by analysis of NMR and MS data. Relative and absolute configurations were assigned on the basis of NOESY data and 1H NMR J-values, comparison of calculated and experimental ECD spectra, and analysis of a Mosher's ester derivative of 2. Several known compounds, including alantrypinone, aspochalasins I and J, methyl 3,4,5-trimethoxy-2((2-((3-pyridinylcarbonyl)amino)benzoyl) amino)benzoate, and trans-dehydrocurvularin were also encountered in the extract of the Hawaiian isolate.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np200958r
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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