Beneficial effects of melatonin on stroke-induced muscle atrophy in focal cerebral ischemic rats = 흰쥐의 국소 뇌허혈성 뇌졸중 후 멜라토닌이 근위축에 미치는 유익한 효과

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Title
Beneficial effects of melatonin on stroke-induced muscle atrophy in focal cerebral ischemic rats = 흰쥐의 국소 뇌허혈성 뇌졸중 후 멜라토닌이 근위축에 미치는 유익한 효과
Author(s)
S Lee; J Shin; Y Hong; M Lee; K Kim; Sang Rae Lee; Kyu Tae Chang; Y Hong
Bibliographic Citation
Laboratory Animal Research, vol. 28, no. 1, pp. 47-54
Publication Year
2012
Abstract
Muscle atrophy is the result of two opposing conditions that can be found in pathological or diseased muscles: an imbalance in protein synthesis and degradation mechanisms. Thus, we investigated whether exogenous melatonin could regulate muscle components in stroke-induced muscle atrophy in rats. Comparing muscle phenotypes, we found that long-term melatonin administration could influence muscle mass. Muscle atrophy-related genes, including muscle atrophy F-box (MAFbx) and muscle ring finger 1 (MuRF1) were significantly down-regulated in melatonin-administered rats in the gastrocnemius. However, only MAFbx at the mRNA level was attenuated in the soleus of melatonin-administered rats. Insulin-like growth factor-1 receptor (IGF-1R) was significantly over-expressed in melatonin-administered rats in both the gastrocnemius and soleus muscles. Comparing myosin heavy chain (MHC) components, in the gastrocnemius, expression of both slow- and fast-type isoforms were significantly enhanced in melatoninadministered rats. These results suggest that long-term exogenous melatonin administration may have a prophylactic effect on muscle atrophy through the MuRF1/MAFbx signaling pathway, as well as a potential therapeutic effect on muscle atrophy through the IGF-1-mediated hypertrophic signaling pathway in a stroke animal model.
Keyword
Melatoninmuscle atrophyfocal cerebral ischemia
ISSN
1738-6055
Publisher
Springer-BMC
DOI
http://dx.doi.org/10.5625/lar.2012.28.1.47
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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