Pro-oncogenic potential of NM23-H2 in hepatocellular carcinoma

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dc.contributor.authorM J Lee-
dc.contributor.authorD Y Xu-
dc.contributor.authorH Li-
dc.contributor.authorG R Yu-
dc.contributor.authorS H Leem-
dc.contributor.authorIn-Sun Chu-
dc.contributor.authorI H Kim-
dc.contributor.authorD G Kim-
dc.date.accessioned2017-04-19T09:29:54Z-
dc.date.available2017-04-19T09:29:54Z-
dc.date.issued2012-
dc.identifier.issnI0000028-
dc.identifier.uri10.3858/emm.2012.44.3.016ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10697-
dc.description.abstractNM23 is a family of structurally and functionally conserved proteins known as nucleoside diphosphate kinases (NDPK). There is abundant mRNA expression of NM23-H1, NM23-H2, or a read through transcript (NM23-LV) in the primary sites of hepatocellular carcinoma (HCC). Although the NM23-H1 protein is implicated as a metastasis suppressor, the role of NM23-H2 appears to be less understood. Thus, the aim of this study was to examine whether NM23-H2 is associated with hepatocarcinogenesis. The level of NM23-H2 expression in tumor tissues and the surrounding matrix appeared to be independent of etiology and tumor differentiation. Its subcellular localization was confined to mainly the cytoplasm and to a lesser extent in the nucleus. Ectopic expression of NM23-H2 in NIH3T3 fibroblasts and HLK3 hepatocytes showed a transformed morphology, enhanced focus formation, and allowed anchorage-independent growth. Finally, NIH3T3 fibroblasts and HLK3 hepatocytes stably expressing NM23-H2 produced tumors in athymic mice and showed c-Myc over-expression. In addition, NF-κB and cyclin D1 expression were also increased by NM23-H2. Lentiviral delivery of NM23-H2 shRNA inhibited tumor growth of xenotransplanted tumors produced from HLK3 cells stably expressing NM23-H2. Collectively, these results indicate that NM23-H2 may be pro-oncogenic in hepatocarcinogenesis.-
dc.publisherSpringer-Nature Pub Group-
dc.titlePro-oncogenic potential of NM23-H2 in hepatocellular carcinoma-
dc.title.alternativePro-oncogenic potential of NM23-H2 in hepatocellular carcinoma-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number3-
dc.citation.endPage224-
dc.citation.startPage214-
dc.citation.volume44-
dc.contributor.affiliatedAuthorIn-Sun Chu-
dc.contributor.alternativeName이미진-
dc.contributor.alternativeNameXu-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName유경란-
dc.contributor.alternativeName임선희-
dc.contributor.alternativeName추인선-
dc.contributor.alternativeName김인희-
dc.contributor.alternativeName김대건-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 44, no. 3, pp. 214-224-
dc.identifier.doi10.3858/emm.2012.44.3.016-
dc.subject.keywordCarcinogenecity tests-
dc.subject.keywordCarcinoma-
dc.subject.keywordCell transformation-
dc.subject.keywordHepatocellular-
dc.subject.keywordNeoplastic-
dc.subject.keywordNM23 nucleoside diphosphate kinases-
dc.subject.keywordOncogenes-
dc.subject.keywordProtooncogene proteins c-myc-
dc.subject.localCarcinogenecity tests-
dc.subject.localCarcinoma-
dc.subject.localCell transformation-
dc.subject.localHepatocellular-
dc.subject.localNeoplastic-
dc.subject.localNM23 nucleoside diphosphate kinases-
dc.subject.localOncogenes-
dc.subject.localOncogene-
dc.subject.localProtooncogene proteins c-myc-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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