DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyung Jae Jung | - |
dc.contributor.author | Young Min Kim | - |
dc.contributor.author | Jang Hoon Kim | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | Ji Young Park | - |
dc.contributor.author | Su-Jin Park | - |
dc.contributor.author | Young Bae Ryu | - |
dc.contributor.author | Woo Song Lee | - |
dc.date.accessioned | 2017-04-19T09:29:57Z | - |
dc.date.available | 2017-04-19T09:29:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.35.786 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10705 | - |
dc.description.abstract | In this study, twelve neuraminidase (NA) inhibitory compounds 1-12 were isolated from heartwood of Caesalpinia sappan on the basis of their biological activities against three types of viral NAs. Of isolated homoisoflavonoids, sappanone A (2) showed the most potent NAs inhibitory activities with IC 50 values of 0.7 μM [H1N1], 1.1 μM [H3N2], and 1.0 μM [H9N2], respectively, whereas saturated homoisoflavonoid (3) did not show significantly inhibition. This result revealed that α,β-unsaturated carbonyl group in A-ring was the key requirements for viral NAs inhibitory activity. In our enzyme kinetic study, all NA inhibitors screened were found to be reversible noncompetitive types. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition = 소목으로부터 분리한 homoisoflavonoids의 viral neuraminidases 저해활성 | - |
dc.title.alternative | Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 790 | - |
dc.citation.startPage | 786 | - |
dc.citation.volume | 35 | - |
dc.contributor.affiliatedAuthor | Hyung Jae Jung | - |
dc.contributor.affiliatedAuthor | Young Min Kim | - |
dc.contributor.affiliatedAuthor | Jang Hoon Kim | - |
dc.contributor.affiliatedAuthor | Ji Young Park | - |
dc.contributor.affiliatedAuthor | Su-Jin Park | - |
dc.contributor.affiliatedAuthor | Young Bae Ryu | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.alternativeName | 정형재 | - |
dc.contributor.alternativeName | 김영민 | - |
dc.contributor.alternativeName | 김장훈 | - |
dc.contributor.alternativeName | 김지영 | - |
dc.contributor.alternativeName | 박지영 | - |
dc.contributor.alternativeName | 박수진 | - |
dc.contributor.alternativeName | 류영배 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 35, no. 5, pp. 786-790 | - |
dc.identifier.doi | 10.1248/bpb.35.786 | - |
dc.subject.keyword | α,β-unsaturated carbonyl | - |
dc.subject.keyword | Caesalpinia sappan | - |
dc.subject.keyword | Homoisoflavonoid | - |
dc.subject.keyword | Neuraminidase | - |
dc.subject.local | α,β-unsaturated carbonyl | - |
dc.subject.local | Caesalpinia sappan | - |
dc.subject.local | Homoisoflavonoid | - |
dc.subject.local | neuraminidase | - |
dc.subject.local | Neuraminidase | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.