Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer

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Title
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer
Author(s)
J J Kim; Jong-Tae Kim; H R Yoon; Min Ah Kang; J H Kim; Y H Lee; Jae Wha KimSeon-Jin Lee; Eun Young Song; P K Myung; Hee Gu Lee
Bibliographic Citation
Tumor Biology, vol. 33, no. 3, pp. 731-738
Publication Year
2012
Abstract
KLK6 encoding kallikrein-related peptidase 6, a trypsin-like serine protease, has been shown to be upregulated in several cancers, although the tumorigenic role of KLK6 has not been elucidated. In this study, KLK6 was identified as a highly upregulated gene in gastric cancer; therefore, the possibility that KLK6 might be a suitable candidate tumor marker was examined. RT-PCR and immunohistochemical analysis showed overexpression of KLK6 in gastric cancer tissues compared to nontumor regions. Sera from gastric cancer patients had a 1.7-fold increase in KLK6 (373.1 μg/L, P=0.048) compared to healthy individuals (214.2 μg/L), although there was no significant difference among patients with various tumor stages. Cellular invasiveness decreased by 45% in cells transfected with KLK6-specific small interfering RNA. Exogenous overexpression of KLK6 led to decreased activity of the E-cadherin promoter. This study shows that KLK6 is significantly upregulated and secreted in gastric cancer tissues and sera, suggesting that KLK6 might be used as a potential biomarker and therapeutic target for gastric cancer.
Keyword
Gastric cancerImmunohistochemistryInvasivenessKallikreinKLK6
ISSN
1010-4283
Publisher
Springer Verlag (Germany)
DOI
http://dx.doi.org/10.1007/s13277-011-0267-1
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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