Inhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.

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dc.contributor.authorY H Kim-
dc.contributor.authorSoo-Jin Choo-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorIck-Dong Yoo-
dc.date.accessioned2017-04-19T09:30:03Z-
dc.date.available2017-04-19T09:30:03Z-
dc.date.issued2012-
dc.identifier.issn1017-7825-
dc.identifier.uri10.4014/jmb.1101.01053ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10716-
dc.description.abstractIn the continued search for melanogenesis inhibitors from microbial metabolites, we found that the culture broth of Clitocybe sp. MKACC 53267 inhibited melanogenesis in B16F10 melanoma cells. The active component was purified by solvent extraction, silica gel chromatography, Sephadex LH-20 column chromatography, and finally by preparative HPLC. Its structure was determined as 5-pentyl-2-furaldehyde on the basis of the UV, NMR, and MS spectroscopic analysis. The 5-pentyl-2-furaldehyde potently inhibited melanogenesis in B16F10 cells with an IC 50 value of 8.4 μg/ml, without cytotoxicity.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleInhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.-
dc.title.alternativeInhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number6-
dc.citation.endPage817-
dc.citation.startPage814-
dc.citation.volume22-
dc.contributor.affiliatedAuthorSoo-Jin Choo-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorIck-Dong Yoo-
dc.contributor.alternativeName김영희-
dc.contributor.alternativeName추수진-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 22, no. 6, pp. 814-817-
dc.identifier.doi10.4014/jmb.1101.01053-
dc.subject.keyword5-penty 1-2-furaldehyde-
dc.subject.keywordB16F10 melanoma-
dc.subject.keywordClitocybe sp-
dc.subject.keywordMelanogenesis-
dc.subject.local5-penty 1-2-furaldehyde-
dc.subject.localB16F10 melanoma-
dc.subject.localClitocybe sp-
dc.subject.localmelanogenesis-
dc.subject.localMelanogenesis-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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