Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell

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Title
Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell
Author(s)
Hee-Sung Chae; Sei Ryang Oh; Hyeong Kyu Lee; S H Joo; Y W Chin
Bibliographic Citation
Food Chemistry, vol. 134, no. 1, pp. 397-400
Publication Year
2012
Abstract
Mangosteen (Garcinia mangostana L.), one of top-selling botanical dietary supplements in the USA, has been used as food and folk medicines in southeastern Asia. Herein, α-and γ-mangostins, major constituents of mangosteen, were investigated for their effect on the bone marrow-derived mast cell (BMMC) mediated allergy mechanism induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. α- and γ-mangostins demonstrated to inhibit Interleukin (IL)-6, prostaglandin D 2 (PGD 2) and leukotriene C 4 (LTC 4) production as well as degranulation in PMA plus A23187 induced BMMC. Furthermore, α- and γ-mangostins were found to repress cyclooxygenase (COX)-2 expression in the present study. Thus, these results suggest that α- and γ-mangostins may be useful in alleviating mast cell-mediated allergic inflammatory responses.
Keyword
α-Mangostinγ-MangostinAllergyBone marrow derived mast cellCyclooxygenase-2DegranulationGarcinia MangostanaInterleukin-6Leukotriene C 4Prostaglandin D 2
ISSN
0308-8146
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.foodchem.2012.02.075
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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