Methanolic extract isolated from root of lycoris aurea inhibits cancer cell growth and endothelial cell tube formation in vitro

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Title
Methanolic extract isolated from root of lycoris aurea inhibits cancer cell growth and endothelial cell tube formation in vitro
Author(s)
Moo Rim Kang; Chang Woo Lee; Ji Eun Yun; Soo Jin Oh; S K Park; K Lee; H M Kim; S B Han; Hyoung-Chin KimJong Soon Kang
Bibliographic Citation
Toxicological Research, vol. 28, no. 1, pp. 33-38
Publication Year
2012
Abstract
In this study, we investigated the effect of methanolic extract isolated from the root of Lycoris aurea (LA) on the growth of cancer cells and the tube formation activity of endothelial cells. Various cancer cells were treated with LA at doses of 0.3, 1, 3, 10 or 30 μg/ml and LA significantly suppressed the growth of several cancer cell lines, including ACHN, HCT-15, K-562, MCF-7, PC-3 and SK-OV-3, in a dose-dependent manner. We also found that LA induced cell cycle arrest at G2/M phase in ACHN renal cell adenocarcinoma cells. Further study demonstrated that LA concentration-dependently inhibited the tube formation, which is a widely used in vitro model of reorganization stage of angiogenesis, in human umbilical vein endothelial cells. Collectively, these results show that LA inhibits the growth of cancer cells and tube formation of endothelial cells and the growth-inhibitory effect of LA might be mediated, at least in part, by blocking cell cycle progression.
Keyword
CancerCell cycleGrowthLycoris aureaTube formation
ISSN
1976-8257
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5487/TR.2012.28.1.033
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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