Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells

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dc.contributor.authorY Asami-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorNak Kyun Soung-
dc.contributor.authorL He-
dc.contributor.authorD O Moon-
dc.contributor.authorJong Won Kim-
dc.contributor.authorH Oh-
dc.contributor.authorM Muroi-
dc.contributor.authorH Osada-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T09:30:18Z-
dc.date.available2017-04-19T09:30:18Z-
dc.date.issued2012-
dc.identifier.issn0968-0896-
dc.identifier.uri10.1016/j.bmc.2012.04.039ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10737-
dc.description.abstractPreviously we reported the identification of a new oxepin-containing diketopiperazine-type marine fungal metabolite, named protuboxepin A which showed antiproliferative activity in several cancer cell lines. In this study we elucidated the mechanism by which protuboxepin A induces cancer cell growth inhibition. Here we report that protuboxepin A induced round-up morphology, M phase arrest, and an increase in the subG 1 population in tumor cells in a dose dependent manner. Our investigations revealed that protuboxepin A directly binds to α,β-tubulin and stabilizes tubulin polymerization thus disrupting microtubule dynamics. This disruption leads to chromosome misalignment and metaphase arrest which induces apoptosis in cancer. Overall, we identified protuboxepin A as a microtubule-stabilizing agent which has a distinctly different chemical structure from previously reported microtubule inhibitors. These results indicate that protuboxepin A has a potential of being a new and effective anti-cancer drug.-
dc.publisherElsevier-
dc.titleProtuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells-
dc.title.alternativeProtuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number12-
dc.citation.endPage3806-
dc.citation.startPage3799-
dc.citation.volume20-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorNak Kyun Soung-
dc.contributor.affiliatedAuthorJong Won Kim-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeNameAsami-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName성낙균-
dc.contributor.alternativeNameHe-
dc.contributor.alternativeName문동오-
dc.contributor.alternativeName김종원-
dc.contributor.alternativeName오현철-
dc.contributor.alternativeNameMuroi-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 20, no. 12, pp. 3799-3806-
dc.identifier.doi10.1016/j.bmc.2012.04.039-
dc.subject.keywordChromosomal misalignment-
dc.subject.keywordMarine fungal metabolite-
dc.subject.keywordMetaphase arrest-
dc.subject.keywordProtuboxepin A-
dc.subject.keywordTubulin-
dc.subject.localChromosomal misalignment-
dc.subject.localMarine fungal metabolite-
dc.subject.localMetaphase arrest-
dc.subject.localProtuboxepin A-
dc.subject.localTubulin-
dc.subject.localtubulin-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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