DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y Asami | - |
dc.contributor.author | Jae-Hyuk Jang | - |
dc.contributor.author | Nak Kyun Soung | - |
dc.contributor.author | L He | - |
dc.contributor.author | D O Moon | - |
dc.contributor.author | Jong Won Kim | - |
dc.contributor.author | H Oh | - |
dc.contributor.author | M Muroi | - |
dc.contributor.author | H Osada | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.date.accessioned | 2017-04-19T09:30:18Z | - |
dc.date.available | 2017-04-19T09:30:18Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | 10.1016/j.bmc.2012.04.039 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10737 | - |
dc.description.abstract | Previously we reported the identification of a new oxepin-containing diketopiperazine-type marine fungal metabolite, named protuboxepin A which showed antiproliferative activity in several cancer cell lines. In this study we elucidated the mechanism by which protuboxepin A induces cancer cell growth inhibition. Here we report that protuboxepin A induced round-up morphology, M phase arrest, and an increase in the subG 1 population in tumor cells in a dose dependent manner. Our investigations revealed that protuboxepin A directly binds to α,β-tubulin and stabilizes tubulin polymerization thus disrupting microtubule dynamics. This disruption leads to chromosome misalignment and metaphase arrest which induces apoptosis in cancer. Overall, we identified protuboxepin A as a microtubule-stabilizing agent which has a distinctly different chemical structure from previously reported microtubule inhibitors. These results indicate that protuboxepin A has a potential of being a new and effective anti-cancer drug. | - |
dc.publisher | Elsevier | - |
dc.title | Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells | - |
dc.title.alternative | Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry | - |
dc.citation.number | 12 | - |
dc.citation.endPage | 3806 | - |
dc.citation.startPage | 3799 | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
dc.contributor.affiliatedAuthor | Nak Kyun Soung | - |
dc.contributor.affiliatedAuthor | Jong Won Kim | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | Asami | - |
dc.contributor.alternativeName | 장재혁 | - |
dc.contributor.alternativeName | 성낙균 | - |
dc.contributor.alternativeName | He | - |
dc.contributor.alternativeName | 문동오 | - |
dc.contributor.alternativeName | 김종원 | - |
dc.contributor.alternativeName | 오현철 | - |
dc.contributor.alternativeName | Muroi | - |
dc.contributor.alternativeName | Osada | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, vol. 20, no. 12, pp. 3799-3806 | - |
dc.identifier.doi | 10.1016/j.bmc.2012.04.039 | - |
dc.subject.keyword | Chromosomal misalignment | - |
dc.subject.keyword | Marine fungal metabolite | - |
dc.subject.keyword | Metaphase arrest | - |
dc.subject.keyword | Protuboxepin A | - |
dc.subject.keyword | Tubulin | - |
dc.subject.local | Chromosomal misalignment | - |
dc.subject.local | Marine fungal metabolite | - |
dc.subject.local | Metaphase arrest | - |
dc.subject.local | Protuboxepin A | - |
dc.subject.local | Tubulin | - |
dc.subject.local | tubulin | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.