A selective Seoul-Fluor-based bioprobe, SfBP, for vaccinia H1-related phosphatase: a dual-specific protein tyrosine phosphatase

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Title
A selective Seoul-Fluor-based bioprobe, SfBP, for vaccinia H1-related phosphatase: a dual-specific protein tyrosine phosphatase
Author(s)
Myeong Seon Jeong; E Kim; Hyo Jin Kang; E J Choi; A R Cho; Sang Jeon Chung; S B Park
Bibliographic Citation
Chemical Communications, vol. 48, no. 52, pp. 6553-6555
Publication Year
2012
Abstract
We report a Seoul-Fluor-based bioprobe, SfBP, for selective monitoring of protein tyrosine phosphatases (PTPs). A rational design based on the structures at the active site of dual-specific PTPs can enable SfBP to selectively monitor the activity of these PTPs with a 93-fold change in brightness. Moreover, screening results of SfBP against 30 classical PTPs and 35 dual-specific PTPs show that it is selective toward vaccinia H1-related (VHR) phosphatase, a dual-specific PTP (DUSP-3).
ISSN
1359-7345
Publisher
Royal Soc Chem
DOI
http://dx.doi.org/10.1039/c2cc31377d
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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