Inhibition of collagen deposit in obstructed rat bladder outlet by transplantation of superparamagnetic iron oxide-labeled human mesenchymal stem cells as monitored by molecular magnetic resonance imaging (MRI)

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dc.contributor.authorH J Lee-
dc.contributor.authorJ H Won-
dc.contributor.authorS H Doo-
dc.contributor.authorJ H Kim-
dc.contributor.authorK Y Song-
dc.contributor.authorS J Lee-
dc.contributor.authorI Lim-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorY S Song-
dc.contributor.authorS U Kim-
dc.date.accessioned2017-04-19T09:31:11Z-
dc.date.available2017-04-19T09:31:11Z-
dc.date.issued2012-
dc.identifier.issn0963-6897-
dc.identifier.uri10.3727/096368911X627516ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10772-
dc.description.abstractBladder outlet obstruction (BOO) caused by collagen deposit is one of the most common problems in elderly males. The present study is to investigate if human mesenchymal stem cells (MSCs) are capable of inhibiting collagen deposition and improve cystometric parameters in bladder outlet obstruction in rats. Human MSCs were labeled with nanoparticles containing superparamagnetic iron oxide (SPION), and transplanted in rat BOO lesion site. Forty 6-week-old female Sprague-Dawley rats were divided into four groups (group 1: control, group 2: sham operation, group 3: BOO, and group 4: BOO rats receiving SPION-hMSCs). Two weeks after the onset of BOO, 1 × 10 6 SPION-hMSCs were injected into the bladder wall. Serial T2- weighted MR images were taken immediately after transplantation of SPION-labeled human MSCs and at 4 weeks posttransplantation. T2-weighted MR images showed a clear hypointense signal induced by the SPION-labeled MSCs. While the expression of collagen and TGF-β protein increased after BOO, the expression of both returned to the original levels after MSC transplantation. Expression of HGF and c-met protein also increased in the group with MSC transplantation. Maximal voiding pressure and residual urine volume increased after BOO but they recovered after MSC transplantation. Human MSCs transplanted in rat BOO models inhibited the bladder fibrosis and mediated recovery of bladder dysfunction. Transplantation of MSCbased cell therapy could be a novel therapeutic strategy against bladder fibrosis in patients with bladder outlet obstruction.-
dc.publisherSage-
dc.titleInhibition of collagen deposit in obstructed rat bladder outlet by transplantation of superparamagnetic iron oxide-labeled human mesenchymal stem cells as monitored by molecular magnetic resonance imaging (MRI)-
dc.title.alternativeInhibition of collagen deposit in obstructed rat bladder outlet by transplantation of superparamagnetic iron oxide-labeled human mesenchymal stem cells as monitored by molecular magnetic resonance imaging (MRI)-
dc.typeArticle-
dc.citation.titleCell Transplantation-
dc.citation.number5-
dc.citation.endPage970-
dc.citation.startPage959-
dc.citation.volume21-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName이홍준-
dc.contributor.alternativeName원정호-
dc.contributor.alternativeName도성환-
dc.contributor.alternativeName김정훈-
dc.contributor.alternativeName송기영-
dc.contributor.alternativeName이선주-
dc.contributor.alternativeName임인자-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName송윤섭-
dc.contributor.alternativeName김승업-
dc.identifier.bibliographicCitationCell Transplantation, vol. 21, no. 5, pp. 959-970-
dc.identifier.doi10.3727/096368911X627516-
dc.subject.keyword(TGF-β)-
dc.subject.keywordBladder outlet obstruction-
dc.subject.keywordCell transplantation-
dc.subject.keywordCollagen-
dc.subject.keywordHuman mesenchymal stem cells (MSCs)-
dc.subject.keywordMagnetic resonance imaging (MRI)-
dc.subject.keywordSuperparamagnetic iron oxide nanoparticle (SPION)-
dc.subject.keywordTransforming growth factor-β-
dc.subject.local(TGF-β)-
dc.subject.localTGF-beta-
dc.subject.localTGFβ-
dc.subject.localTGF-β-
dc.subject.localTGF beta-
dc.subject.localBladder outlet obstruction-
dc.subject.localCell transplantation-
dc.subject.localCollagen-
dc.subject.localcollagen-
dc.subject.localHuman mesenchymal stem cells (hMSCs)-
dc.subject.localhuman mesenchymal stem cells-
dc.subject.localHuman mesenchymal stem cells-
dc.subject.localHuman mesenchymal stem cells (MSCs)-
dc.subject.localmagnetic resonance imaging (MRI)-
dc.subject.localMagnetic Resonance Imaging-
dc.subject.localmagnetic resonance imaging-
dc.subject.localMagnetic resonance imaging-
dc.subject.localMRI-
dc.subject.localMagnetic resonance imaging (MRI)-
dc.subject.localSuperparamagnetic iron oxide nanoparticle (SPION)-
dc.subject.localTransforming growth factor β-
dc.subject.localTransforming growth factor-β-
dc.subject.localTransforming growth factor beta-
dc.description.journalClassY-
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