Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Oh Hyung Kwon | - |
| dc.contributor.author | T W Kang | - |
| dc.contributor.author | Jeong Hwan Kim | - |
| dc.contributor.author | Mirang Kim | - |
| dc.contributor.author | S M Noh | - |
| dc.contributor.author | K S Song | - |
| dc.contributor.author | Hyang Sook Yoo | - |
| dc.contributor.author | W H Kim | - |
| dc.contributor.author | Z Xie | - |
| dc.contributor.author | D Pocalyko | - |
| dc.contributor.author | Seon-Young Kim | - |
| dc.contributor.author | Yong Sung Kim | - |
| dc.date.accessioned | 2017-04-19T09:31:11Z | - |
| dc.date.available | 2017-04-19T09:31:11Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier.issn | 0006-291X | - |
| dc.identifier.uri | 10.1016/j.bbrc.2012.05.063 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10778 | - |
| dc.description.abstract | PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase that promotes aerobic glycolysis. Here, we describe an important role for PKM2 in regulating the survival of gastric cancer (GC) cells. We showed that PKM2 was overexpressed in gastric tumor tissues compared to normal tissues and its expression level was associated with poor survival of gastric cancer patients. We also showed that PKM2 affected cell survival by regulating Bcl-xL at the transcriptional level. PKM2 knockdown partially affected the stability of NF-kB subunit p65, suggesting that post-translational regulation of p65 by PKM2 is one of plausible mechanisms for the increased cell growth. Therefore, PKM2 may function as an upstream molecule that regulates p65 function and thus enhances the growth of tumor cells. | - |
| dc.publisher | Elsevier | - |
| dc.title | Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level | - |
| dc.title.alternative | Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level | - |
| dc.type | Article | - |
| dc.citation.title | Biochemical and Biophysical Research Communications | - |
| dc.citation.number | 1 | - |
| dc.citation.endPage | 44 | - |
| dc.citation.startPage | 38 | - |
| dc.citation.volume | 423 | - |
| dc.contributor.affiliatedAuthor | Oh Hyung Kwon | - |
| dc.contributor.affiliatedAuthor | Jeong Hwan Kim | - |
| dc.contributor.affiliatedAuthor | Mirang Kim | - |
| dc.contributor.affiliatedAuthor | Hyang Sook Yoo | - |
| dc.contributor.affiliatedAuthor | Seon-Young Kim | - |
| dc.contributor.affiliatedAuthor | Yong Sung Kim | - |
| dc.contributor.alternativeName | 권오형 | - |
| dc.contributor.alternativeName | 강태욱 | - |
| dc.contributor.alternativeName | 김정환 | - |
| dc.contributor.alternativeName | 김미랑 | - |
| dc.contributor.alternativeName | 노승무 | - |
| dc.contributor.alternativeName | 송규상 | - |
| dc.contributor.alternativeName | 유향숙 | - |
| dc.contributor.alternativeName | 김우호 | - |
| dc.contributor.alternativeName | Xie | - |
| dc.contributor.alternativeName | Pocalyko | - |
| dc.contributor.alternativeName | 김선영 | - |
| dc.contributor.alternativeName | 김용성 | - |
| dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 423, no. 1, pp. 38-44 | - |
| dc.identifier.doi | 10.1016/j.bbrc.2012.05.063 | - |
| dc.subject.keyword | Bcl-xL | - |
| dc.subject.keyword | Gastric cancer | - |
| dc.subject.keyword | NF-κB | - |
| dc.subject.keyword | PKM2 | - |
| dc.subject.local | BCL-xL | - |
| dc.subject.local | Bcl-XL | - |
| dc.subject.local | Bcl-xL | - |
| dc.subject.local | Gastric cancer | - |
| dc.subject.local | Gastric cancer (GC) | - |
| dc.subject.local | gastric cancer | - |
| dc.subject.local | Gastric Cancer | - |
| dc.subject.local | NFkappaB | - |
| dc.subject.local | NFκB | - |
| dc.subject.local | Nf-κB | - |
| dc.subject.local | Nf-κb | - |
| dc.subject.local | Nuclear factor (NF)-κB | - |
| dc.subject.local | Nuclear factor kappa B | - |
| dc.subject.local | Nuclear factor kappaB | - |
| dc.subject.local | Nuclear factor κB | - |
| dc.subject.local | Nuclear factor κB (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappa B | - |
| dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappaB | - |
| dc.subject.local | Nuclear factor-κB | - |
| dc.subject.local | Nuclear factor-κb | - |
| dc.subject.local | NF-kB | - |
| dc.subject.local | NF-kappa B | - |
| dc.subject.local | NF-kappaB | - |
| dc.subject.local | NF-ΚB | - |
| dc.subject.local | NF-κ B | - |
| dc.subject.local | NF-κB | - |
| dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
| dc.subject.local | nuclear factor kappa B | - |
| dc.subject.local | nuclear factor κB | - |
| dc.subject.local | nuclear factor-kappaB | - |
| dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
| dc.subject.local | nuclear factor-κB | - |
| dc.subject.local | nuclear factorκB | - |
| dc.subject.local | PKM2 | - |
| dc.description.journalClass | Y | - |
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