CACG: a database for comparative analysis of conjoined genes

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Title
CACG: a database for comparative analysis of conjoined genes
Author(s)
Dae Soo Kim; Dong-Wook Kim; M Y Kim; S H Nam; Sang-Haeng Choi; Ryong Nam Kim; Aram Kang; Aeri Kim; Hong-Seog Park
Bibliographic Citation
Genomics, vol. 100, no. 1, pp. 14-17
Publication Year
2012
Abstract
A conjoined gene is defined as one formed at the time of transcription by combining at least part of one exon from each of two or more distinct genes that lie on the same chromosome, in the same or opposite orientation, which translate independently into different proteins. We comparatively studied the extent of conjoined genes in thirteen genomes by analyzing the public databases of expressed sequence tags and mRNA sequences using a set of computational tools designed to identify conjoined genes on the same DNA strand or opposite DNA strands of the same genomic locus. The CACG database, available at http://cgc.kribb.re.kr/map/, includes a number of conjoined genes (7131-human, 2-chimpanzee, 5-orangutan, 57-chicken, 4-rhesus monkey, 651-cow, 27-dog, 2512-mouse, 263-rat, 1482-zebrafish, 5-horse, 29-sheep, and 8-medaka) and is very effective and easy to use to analyze the evolutionary process of conjoined genes when comparing different species.
Keyword
BioinformaticsConjoined gene
ISSN
0888-7543
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ygeno.2012.05.005
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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