Charge-conversional poly(amino acid)s derivatives as a drug delivery carrier in response to the tumor environment

Cited 14 time in scopus
Metadata Downloads
Title
Charge-conversional poly(amino acid)s derivatives as a drug delivery carrier in response to the tumor environment
Author(s)
S R Yoon; H M Yang; C W Park; S Lim; Bong Hyun Chung; J D Kim
Bibliographic Citation
Journal of Biomedical Materials Research Part A, vol. 100, no. 8, pp. 2027-2033
Publication Year
2012
Abstract
A charge-converting and pH-dependent nanocarrier was achieved by conjugating 2,3-dimethylmaleic anhydride (DMMA) to the amino group of an octadecyl grafted poly (2-hydroxyethyl aspartamide) (PHEA-g-C 18-NH 2) backbone, thereby forming a spherical micelle. PHEA, a poly(amino acid)s derivative, was derived from poly(succinimide), which is biocompatible and biodegradable. DMMA, a detachable component at the tumor site, was added, preventing aggregation with negative blood serum and enhancing the nanocarrier's cellular uptake. The polymeric micelle was comprehensively characterized and doxorubicin was encapsulated successively. The cellular uptake and anticancer therapeutic effect were evaluated by flow cytometry, confocal laser scanning microscopy, and a MTT assay. The properties of the nanocarrier can further be exploited to develop an early detection module for cancer. The present work is also expected to advance the study of designing smart carriers for drug and gene delivery.
Keyword
amphiphilic graft polymerpH-sensitive polymerspoly(2-hydroxyethyl aspartamide)poly(amino acid)s
ISSN
1549-3296
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/jbm.a.34048
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.