DC Field | Value | Language |
---|---|---|
dc.contributor.author | A J Minn | - |
dc.contributor.author | E Bevilacqua | - |
dc.contributor.author | Ji Eun Yun | - |
dc.contributor.author | M R Rosner | - |
dc.date.accessioned | 2017-04-19T09:32:09Z | - |
dc.date.available | 2017-04-19T09:32:09Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1538-4101 | - |
dc.identifier.uri | 10.4161/cc.20624 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10799 | - |
dc.description.abstract | Cancer lethality is mainly caused by metastasis. Therefore, understanding the nature of the genes involved in this process has become a priority. Given the heterogeneity of mutations in cancer cells, considerable focus has been directed toward characterizing metastasis genes in the context of relevant signaling pathways rather than treating genes as independent and equal entities. One signaling cascade implicated in the regulation of cell growth, invasion and metastasis is the MAP kinase pathway. Raf kinase inhibitory protein (RKIP) functions as an inhibitor of the MAP kinase pathway and is a metastasis suppressor in different cancer models. By utilizing statistical analysis of clinical data integrated with experimental validation, we recently identified components of the RKIP signaling pathway relevant to breast cancer metastasis. Using the RKIP pathway as an example, we show how prior biological knowledge can be efficiently combined with genome-wide patient data to identify gene regulatory mechanisms that control metastasis. | - |
dc.publisher | T&F (Taylor & Francis) | - |
dc.title | Identification of novel metastasis suppressor signaling pathways for breast cancer | - |
dc.title.alternative | Identification of novel metastasis suppressor signaling pathways for breast cancer | - |
dc.type | Article | - |
dc.citation.title | Cell Cycle | - |
dc.citation.number | 13 | - |
dc.citation.endPage | 2457 | - |
dc.citation.startPage | 2452 | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Ji Eun Yun | - |
dc.contributor.alternativeName | Minn | - |
dc.contributor.alternativeName | Bevilacqua | - |
dc.contributor.alternativeName | 윤지은 | - |
dc.contributor.alternativeName | Rosner | - |
dc.identifier.bibliographicCitation | Cell Cycle, vol. 11, no. 13, pp. 2452-2457 | - |
dc.identifier.doi | 10.4161/cc.20624 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Gene set analysis | - |
dc.subject.keyword | Gene set enrichment analysis | - |
dc.subject.keyword | Gene signature | - |
dc.subject.keyword | Invasion | - |
dc.subject.keyword | Metastasis | - |
dc.subject.keyword | Raf kinase inhibitory protein | - |
dc.subject.keyword | Random forests | - |
dc.subject.keyword | Signaling pathway | - |
dc.subject.local | breast cancer | - |
dc.subject.local | Breast cancer | - |
dc.subject.local | Breast Cancer | - |
dc.subject.local | Gene set analysis | - |
dc.subject.local | Gene set enrichment analysis | - |
dc.subject.local | Gene set enrichment analysis (GSEA) | - |
dc.subject.local | Gene signature | - |
dc.subject.local | gene signature | - |
dc.subject.local | invasion | - |
dc.subject.local | Invasion | - |
dc.subject.local | metastasis | - |
dc.subject.local | Metastasis | - |
dc.subject.local | Raf kinase inhibitory protein | - |
dc.subject.local | Random forest | - |
dc.subject.local | random forest | - |
dc.subject.local | Random forests | - |
dc.subject.local | Random Forest | - |
dc.subject.local | Signaling pathways | - |
dc.subject.local | signaling pathways | - |
dc.subject.local | Signaling pathway | - |
dc.description.journalClass | Y | - |
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