ESM-1 regulates cell growth and metastatic process through activation of NF-kB in colorectal cancer

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dc.contributor.authorYun Hee Kang-
dc.contributor.authorN Y Ji-
dc.contributor.authorS R Han-
dc.contributor.authorC I Lee-
dc.contributor.authorJae Wha Kim-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorY H Kim-
dc.contributor.authorH K Chun-
dc.contributor.authorJ W Kim-
dc.contributor.authorJ W Chung-
dc.contributor.authorD K Ahn-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorEun Young Song-
dc.date.accessioned2017-04-19T09:32:09Z-
dc.date.available2017-04-19T09:32:09Z-
dc.date.issued2012-
dc.identifier.issn08986568-
dc.identifier.uri10.1016/j.cellsig.2012.06.004ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10801-
dc.description.abstractIn our previous study, we reported that endothelial cell specific molecule-1 (ESM-1) was increased in tissue and serum from colorectal cancer patients and suggested that ESM-1 can be used as a potential serum marker for early detection of colorectal cancer. The aim of this study was to evaluate the role of ESM-1 as an intracellular molecule in colorectal cancer. ESM-1 expression was knocked down by small interfering RNA (siRNA) in colorectal cancer cells. Expression of ESM-1 siRNA decreased cell survival through the Akt-dependent inhibition of NF-κB/IκB pathway and an interconnected reduction in phospho-Akt, -p38, -ERK1, -RSK1, -GSK-3α/β and -HSP27, as determined by a phospho-MAPK array. ESM-1 silencing induced G 1 phase cell cycle arrest by induction of PTEN, resulting in the inhibition of cyclin D1 and inhibited cell migration and invasion of COLO205 cells. Consistently, ESM-1 overexpression in HCT-116 cells enhanced cell proliferation through the Akt-dependent activation of NF-κB pathway. In addition, ESM-1 interacted with NF-κB and activated NF-κB promoter. This study demonstrates that ESM-1 is involved in cell survival, cell cycle progression, migration, invasion and EMT during tumor invasion in colorectal cancer. Based on our results, ESM-1 may be a useful therapeutic target for colorectal cancer.-
dc.publisherElsevier-
dc.titleESM-1 regulates cell growth and metastatic process through activation of NF-kB in colorectal cancer-
dc.title.alternativeESM-1 regulates cell growth and metastatic process through activation of NF-kB in colorectal cancer-
dc.typeArticle-
dc.citation.titleCellular Signalling-
dc.citation.number10-
dc.citation.endPage1949-
dc.citation.startPage1940-
dc.citation.volume24-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName강윤희-
dc.contributor.alternativeName지나영-
dc.contributor.alternativeName한승로-
dc.contributor.alternativeName이정일-
dc.contributor.alternativeName김재화-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName전호경-
dc.contributor.alternativeName김종완-
dc.contributor.alternativeName정진웅-
dc.contributor.alternativeName안동국-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName송은영-
dc.identifier.bibliographicCitationCellular Signalling, vol. 24, no. 10, pp. 1940-1949-
dc.identifier.doi10.1016/j.cellsig.2012.06.004-
dc.subject.keywordCell growth-
dc.subject.keywordColorectal cancer-
dc.subject.keywordESM-1-
dc.subject.keywordMetastatic process-
dc.subject.keywordNF-κB activation-
dc.subject.localCell growth-
dc.subject.localColorectal cancer-
dc.subject.localESM-1-
dc.subject.localMetastatic process-
dc.subject.localNF-κB activation-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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