Effects of fenvalerate on apoptosis level and GFAP expression in the brain tissue of the pale chub = Fenvalerate가 피라미(Zacco platypus) 뇌 조직에서 apoptosis 정도와 GFAP 발현에 미치는 영향

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Title
Effects of fenvalerate on apoptosis level and GFAP expression in the brain tissue of the pale chub = Fenvalerate가 피라미(Zacco platypus) 뇌 조직에서 apoptosis 정도와 GFAP 발현에 미치는 영향
Author(s)
S W Kim; N K Park; Sang Rae Lee; D S Reu
Bibliographic Citation
Korean Journal of Microscopy, vol. 42, no. 2, pp. 53-59
Publication Year
2012
Abstract
We evaluated the level of toxicity by LC50 and investigated the mechanism of brain impairment and GFAP expression by light and fluorescence microscopes in the pale chub, Zacco platypus, treated with fenvalerate. Survival rate was decreased according to the rise of fenvalerate concentration, and LC50 concentration was 27.79 μg/L. Apoptosis was increased according to the rise of fenvalerate concentration by TUNEL assay which determine apoptotic cell death population. Also, GFAP expression was increased in the periventricular zone. These results suggest that apoptosis might be a major mechanism to brain impairment of the pale chub by fenvalrerate. Increased GFAP expression in the periventricular zone would be an index of brain impairment. Taken together, this study might contribute to reveal the pathological mechanism of fish brain impairment by insecticide of pyrethroid, and to be an useful basic data for preservation of aquatic ecosystem.
Keyword
ApoptosisBrainFenvalerateGFAPZacco platypus
ISSN
1225-6773
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.9729/AM.2012.42.2.053
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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