Autophagy contributes to retardation of cardiac growth in diabetic rats = 세포자가포식 작용에서 심장의 성장을 지연시키는데 기여하는 당뇨병 쥐

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Title
Autophagy contributes to retardation of cardiac growth in diabetic rats = 세포자가포식 작용에서 심장의 성장을 지연시키는데 기여하는 당뇨병 쥐
Author(s)
Youngjeon Lee; Y Hong; Sang Rae Lee; Kyu Tae Chang; Yonggeun Hong
Bibliographic Citation
Laboratory Animal Research, vol. 28, no. 2, pp. 99-107
Publication Year
2012
Abstract
Diabetes mellitus is a major predictor of heart failure, although the mechanisms by which the disease causes cardiomyopathy are not well understood. The purpose of this study was to determine whether prolonged exposure of cardiomyocytes to high glucose concentrations induces autophagy and contributes to cardiomyopathy. Interestingly, there were no differences in the autophagic activation produced by different glucose concentrations. However, cell viability was decreased by high glucose. In the diabetic rats, we found a higher level of microtubule-associated protein light chain 3 (LC3) expression and a reduction in the size of the left ventricle (LV) (P<0.05) caused by growth retardation, suggesting activated autophagy. Our in vitro findings indicate that hyperglycemic oxidative stress induces autophagy, and our in vivo studies reveal that autophagy is involved in the progression of pathophysiological remodeling of the heart. Taken together, the studies suggest that autophagy may play a role in the pathogenesis of juvenile diabetic cardiomyopathy.
Keyword
Autophagycardiomyopathydiabetesgrowth retardationhyperglycemia
ISSN
1738-6055
Publisher
South Korea
DOI
http://dx.doi.org/10.5625/lar.2012.28.2.99
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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