Melatonin combined with exercise cannot alleviate cerebral injury in a rat model of focal cerebral ischemia/reperfusion injury = 국소 뇌허혈-재관류 손상 쥐 모델에서 뇌손상을 완화시키지 못하는 멜라토닌과 운동의 동시 적용

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Title
Melatonin combined with exercise cannot alleviate cerebral injury in a rat model of focal cerebral ischemia/reperfusion injury = 국소 뇌허혈-재관류 손상 쥐 모델에서 뇌손상을 완화시키지 못하는 멜라토닌과 운동의 동시 적용
Author(s)
S Lee; J Shin; M Lee; Y Hong; S K Lee; Youngjeon Lee; T Lkhagvasuren; D W Kim; Y A Yang; Kyu Tae Chang; Y Hong
Bibliographic Citation
Neural Regeneration Research, vol. 7, no. 13, pp. 993-999
Publication Year
2012
Abstract
Previous studies have demonstrated that melatonin combined with exercise can alleviate secondary damage after spinal cord injury in rats. Therefore, it is hypothesized that melatonin combined with exercise can also alleviate ischemic brain damage. In this study, adult rats were subjected to right middle cerebral artery occlusion after receiving 10 mg/kg melatonin or vehicle subcutaneously twice daily for 14 days. Forced exercise using an animal treadmill was performed at 20 m/min for 30 minutes per day for 6 days prior to middle cerebral artery occlusion. After middle cerebral artery occlusion, each rat received melatonin combined with exercise, melatonin or exercise alone equally for 7 days until sacrifice. Interestingly, rats receiving melatonin combined with exercise exhibited more severe neurological deficits than those receiving melatonin or exercise alone. Hypoxia-inducible factor 1α mRNA in the brain tissue was upregulated in rats receiving melatonin combined with exercise. Similarly, microtubule associated protein-2 mRNA expression was significantly upregulated in rats receiving melatonin alone. Chondroitin sulfate proteoglycan 4 (NG2) mRNA expression was significantly decreased in rats receiving melatonin combined with exercise as well as in rats receiving exercise alone. Furthermore, neural cell loss in the primary motor cortex was significantly reduced in rats receiving melatonin or exercise alone, but the change was not observed in rats receiving melatonin combined with exercise. These findings suggest that excessive intervention with melatonin, exercise or their combination may lead to negative effects on ischemia/reperfusion-induced brain damage.
Keyword
Brain tissue lossChondroitin sulfate proteoglycan 4ExerciseFocal cerebral ischemia/reperfusionHypoxia-inducible factor 1 alphaMelatoninMicrotubule associated protein-2Neural regenerationNG2Neurological function
ISSN
1673-5374
Publisher
Kluwer
DOI
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.13.005
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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