Large-scale transcriptome sequencing and gene analyses in the crab-eating macaque (macaca fascicularis) for biomedical research = 게잡이 원숭이의 대량 전사체 및 유전자 분석

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dc.contributor.authorJae Won Huh-
dc.contributor.authorYoung-Hyun Kim-
dc.contributor.authorSang Je Park-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorSang Rae Lee-
dc.contributor.authorKyeong Min Kim-
dc.contributor.authorKang Jin Jeong-
dc.contributor.authorJi Su Kim-
dc.contributor.authorBong Seok Song-
dc.contributor.authorBo Woong Sim-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorSang-Hyun Kim-
dc.contributor.authorKyu Tae Chang-
dc.date.accessioned2017-04-19T09:32:17Z-
dc.date.available2017-04-19T09:32:17Z-
dc.date.issued2012-
dc.identifier.issn1471-2164-
dc.identifier.uri10.1186/1471-2164-13-163ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10818-
dc.description.abstractBackground: As a human mimic, the crab-eating macaque (Macaca fascicularis) is an invaluable non-human primate model for biomedical research, but the lack of genetic information on this primate has represented a significant obstacle for its broader use. Results: Here, we sequenced the transcriptome of 16 tissues and identified genes to resolve the main obstacles for understanding the biological response of the crab-eating macaque. From 4 million reads with 1.4 billion base sequences, 31,786 isotigs containing genes similar to those of humans, 12,672 novel isotigs, and 348,160 singletons were identified using the GS FLX sequencing method. Approximately 86% of human genes were represented among the genes sequenced in this study. Additionally, 175 tissue-specific genes were identified, 81 of which were experimentally validated. In total, 4,314 alternative splicing (AS) events were identified and analyzed. Intriguingly, 10.4% of AS events were associated with transposable element (TE) insertions. Finally, investigation of TE exonization events and evolutionary analysis were conducted, revealing interesting phenomena of human-specific amplified trends in TE exonization events. Conclusions: This report represents the first large-scale transcriptome sequencing and genetic analyses of M. fascicularis and could contribute to its utility for biomedical research and basic biology.-
dc.publisherSpringer-BMC-
dc.titleLarge-scale transcriptome sequencing and gene analyses in the crab-eating macaque (macaca fascicularis) for biomedical research = 게잡이 원숭이의 대량 전사체 및 유전자 분석-
dc.title.alternativeLarge-scale transcriptome sequencing and gene analyses in the crab-eating macaque (macaca fascicularis) for biomedical research-
dc.typeArticle-
dc.citation.titleBMC Genomics-
dc.citation.number0-
dc.citation.endPage163-
dc.citation.startPage163-
dc.citation.volume13-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorYoung-Hyun Kim-
dc.contributor.affiliatedAuthorSang Je Park-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.affiliatedAuthorSang Rae Lee-
dc.contributor.affiliatedAuthorKyeong Min Kim-
dc.contributor.affiliatedAuthorKang Jin Jeong-
dc.contributor.affiliatedAuthorJi Su Kim-
dc.contributor.affiliatedAuthorBong Seok Song-
dc.contributor.affiliatedAuthorBo Woong Sim-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorSang-Hyun Kim-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김영현-
dc.contributor.alternativeName박상제-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName김경민-
dc.contributor.alternativeName정강진-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName송봉석-
dc.contributor.alternativeName심보웅-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName김상현-
dc.contributor.alternativeName장규태-
dc.identifier.bibliographicCitationBMC Genomics, vol. 13, pp. 163-163-
dc.identifier.doi10.1186/1471-2164-13-163-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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